The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma)

Stephane Chauvie, Fabrizio Bergesio, Federica Fioroni, Marco Brambilla, Alberto Biggi, Annibale Versari, Luca Guerra, Giovanni Storto, Pellegrino Musto, Stefano Luminari, Maria G. Cabras, Monica Balzarotti, Luigi Rigacci, Maurizio Martelli, Umberto Vitolo, Massimo Federico, Andrea Gallamini

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: The quantitative assessment of Positron Emission Tomography (PET) scans using standardized uptake value and derived parameters proved to be superior to traditional qualitative assessment in several retrospective or mono-centric prospective reports. Since different scanners give different quantitative readings, a program for clinical trial qualification (CTQ) is mandatory to guarantee a reliable and reproducible use of quantitative PET in prospective multi-centre clinical trials and in every-day clinical life. Methods: We set up, under the auspices of Italian Foundation on Lymphoma (FIL), a CTQ program consisting of the PET/CT scan acquisition and analysis of 18F and 68Ge NEMA/IEC image quality phantoms for the reduction of inter-scanner variability. Variability was estimated on background activity concentration (BAC) and sphere to background ratio (SBR). Results: The use of a 68Ge phantom allowed reducing the inter-scanner variability among different scanners from 74.0% to 20.5% in BAC and from 63.3% to 17.4% in SBR compared to using the 18F phantom. The CTQ criteria were fulfilled at first round in 100% and 28% of PET scanners with 68Ge and 18F respectively. Conclusions: The 68Ge phantom proved a reliable tool for PET scanner qualification, able to significantly reduce the potential sources of error while increasing the reproducibility of PET derived quantitative parameter measurement.

Original languageEnglish
Pages (from-to)651-6
Number of pages6
JournalPhysica Medica
Volume32
Issue number5
DOIs
Publication statusPublished - May 1 2016

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qualifications
Positron-Emission Tomography
scanners
positrons
Lymphoma
tomography
Clinical Trials
Reading
acquisition
Research Design

Keywords

  • Clinical trials
  • Lymphoma
  • Positron emission tomography
  • Quantitative imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma). / Chauvie, Stephane; Bergesio, Fabrizio; Fioroni, Federica; Brambilla, Marco; Biggi, Alberto; Versari, Annibale; Guerra, Luca; Storto, Giovanni; Musto, Pellegrino; Luminari, Stefano; Cabras, Maria G.; Balzarotti, Monica; Rigacci, Luigi; Martelli, Maurizio; Vitolo, Umberto; Federico, Massimo; Gallamini, Andrea.

In: Physica Medica, Vol. 32, No. 5, 01.05.2016, p. 651-6.

Research output: Contribution to journalArticle

Chauvie, S, Bergesio, F, Fioroni, F, Brambilla, M, Biggi, A, Versari, A, Guerra, L, Storto, G, Musto, P, Luminari, S, Cabras, MG, Balzarotti, M, Rigacci, L, Martelli, M, Vitolo, U, Federico, M & Gallamini, A 2016, 'The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma)', Physica Medica, vol. 32, no. 5, pp. 651-6. https://doi.org/10.1016/j.ejmp.2016.04.004
Chauvie, Stephane ; Bergesio, Fabrizio ; Fioroni, Federica ; Brambilla, Marco ; Biggi, Alberto ; Versari, Annibale ; Guerra, Luca ; Storto, Giovanni ; Musto, Pellegrino ; Luminari, Stefano ; Cabras, Maria G. ; Balzarotti, Monica ; Rigacci, Luigi ; Martelli, Maurizio ; Vitolo, Umberto ; Federico, Massimo ; Gallamini, Andrea. / The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma). In: Physica Medica. 2016 ; Vol. 32, No. 5. pp. 651-6.
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T1 - The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma)

AU - Chauvie, Stephane

AU - Bergesio, Fabrizio

AU - Fioroni, Federica

AU - Brambilla, Marco

AU - Biggi, Alberto

AU - Versari, Annibale

AU - Guerra, Luca

AU - Storto, Giovanni

AU - Musto, Pellegrino

AU - Luminari, Stefano

AU - Cabras, Maria G.

AU - Balzarotti, Monica

AU - Rigacci, Luigi

AU - Martelli, Maurizio

AU - Vitolo, Umberto

AU - Federico, Massimo

AU - Gallamini, Andrea

PY - 2016/5/1

Y1 - 2016/5/1

N2 - Purpose: The quantitative assessment of Positron Emission Tomography (PET) scans using standardized uptake value and derived parameters proved to be superior to traditional qualitative assessment in several retrospective or mono-centric prospective reports. Since different scanners give different quantitative readings, a program for clinical trial qualification (CTQ) is mandatory to guarantee a reliable and reproducible use of quantitative PET in prospective multi-centre clinical trials and in every-day clinical life. Methods: We set up, under the auspices of Italian Foundation on Lymphoma (FIL), a CTQ program consisting of the PET/CT scan acquisition and analysis of 18F and 68Ge NEMA/IEC image quality phantoms for the reduction of inter-scanner variability. Variability was estimated on background activity concentration (BAC) and sphere to background ratio (SBR). Results: The use of a 68Ge phantom allowed reducing the inter-scanner variability among different scanners from 74.0% to 20.5% in BAC and from 63.3% to 17.4% in SBR compared to using the 18F phantom. The CTQ criteria were fulfilled at first round in 100% and 28% of PET scanners with 68Ge and 18F respectively. Conclusions: The 68Ge phantom proved a reliable tool for PET scanner qualification, able to significantly reduce the potential sources of error while increasing the reproducibility of PET derived quantitative parameter measurement.

AB - Purpose: The quantitative assessment of Positron Emission Tomography (PET) scans using standardized uptake value and derived parameters proved to be superior to traditional qualitative assessment in several retrospective or mono-centric prospective reports. Since different scanners give different quantitative readings, a program for clinical trial qualification (CTQ) is mandatory to guarantee a reliable and reproducible use of quantitative PET in prospective multi-centre clinical trials and in every-day clinical life. Methods: We set up, under the auspices of Italian Foundation on Lymphoma (FIL), a CTQ program consisting of the PET/CT scan acquisition and analysis of 18F and 68Ge NEMA/IEC image quality phantoms for the reduction of inter-scanner variability. Variability was estimated on background activity concentration (BAC) and sphere to background ratio (SBR). Results: The use of a 68Ge phantom allowed reducing the inter-scanner variability among different scanners from 74.0% to 20.5% in BAC and from 63.3% to 17.4% in SBR compared to using the 18F phantom. The CTQ criteria were fulfilled at first round in 100% and 28% of PET scanners with 68Ge and 18F respectively. Conclusions: The 68Ge phantom proved a reliable tool for PET scanner qualification, able to significantly reduce the potential sources of error while increasing the reproducibility of PET derived quantitative parameter measurement.

KW - Clinical trials

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KW - Positron emission tomography

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