Abstract
Purpose: The quantitative assessment of Positron Emission Tomography (PET) scans using standardized uptake value and derived parameters proved to be superior to traditional qualitative assessment in several retrospective or mono-centric prospective reports. Since different scanners give different quantitative readings, a program for clinical trial qualification (CTQ) is mandatory to guarantee a reliable and reproducible use of quantitative PET in prospective multi-centre clinical trials and in every-day clinical life. Methods: We set up, under the auspices of Italian Foundation on Lymphoma (FIL), a CTQ program consisting of the PET/CT scan acquisition and analysis of 18F and 68Ge NEMA/IEC image quality phantoms for the reduction of inter-scanner variability. Variability was estimated on background activity concentration (BAC) and sphere to background ratio (SBR). Results: The use of a 68Ge phantom allowed reducing the inter-scanner variability among different scanners from 74.0% to 20.5% in BAC and from 63.3% to 17.4% in SBR compared to using the 18F phantom. The CTQ criteria were fulfilled at first round in 100% and 28% of PET scanners with 68Ge and 18F respectively. Conclusions: The 68Ge phantom proved a reliable tool for PET scanner qualification, able to significantly reduce the potential sources of error while increasing the reproducibility of PET derived quantitative parameter measurement.
| Original language | English |
|---|---|
| Pages (from-to) | 651-6 |
| Number of pages | 6 |
| Journal | Physica Medica |
| Volume | 32 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1 2016 |
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Keywords
- Clinical trials
- Lymphoma
- Positron emission tomography
- Quantitative imaging
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Physics and Astronomy(all)
Cite this
The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma). / Chauvie, Stephane; Bergesio, Fabrizio; Fioroni, Federica; Brambilla, Marco; Biggi, Alberto; Versari, Annibale; Guerra, Luca; Storto, Giovanni; Musto, Pellegrino; Luminari, Stefano; Cabras, Maria G.; Balzarotti, Monica; Rigacci, Luigi; Martelli, Maurizio; Vitolo, Umberto; Federico, Massimo; Gallamini, Andrea.
In: Physica Medica, Vol. 32, No. 5, 01.05.2016, p. 651-6.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The 68Ge phantom-based FDG-PET site qualification program for clinical trials adopted by FIL (Italian Foundation on Lymphoma)
AU - Chauvie, Stephane
AU - Bergesio, Fabrizio
AU - Fioroni, Federica
AU - Brambilla, Marco
AU - Biggi, Alberto
AU - Versari, Annibale
AU - Guerra, Luca
AU - Storto, Giovanni
AU - Musto, Pellegrino
AU - Luminari, Stefano
AU - Cabras, Maria G.
AU - Balzarotti, Monica
AU - Rigacci, Luigi
AU - Martelli, Maurizio
AU - Vitolo, Umberto
AU - Federico, Massimo
AU - Gallamini, Andrea
PY - 2016/5/1
Y1 - 2016/5/1
N2 - Purpose: The quantitative assessment of Positron Emission Tomography (PET) scans using standardized uptake value and derived parameters proved to be superior to traditional qualitative assessment in several retrospective or mono-centric prospective reports. Since different scanners give different quantitative readings, a program for clinical trial qualification (CTQ) is mandatory to guarantee a reliable and reproducible use of quantitative PET in prospective multi-centre clinical trials and in every-day clinical life. Methods: We set up, under the auspices of Italian Foundation on Lymphoma (FIL), a CTQ program consisting of the PET/CT scan acquisition and analysis of 18F and 68Ge NEMA/IEC image quality phantoms for the reduction of inter-scanner variability. Variability was estimated on background activity concentration (BAC) and sphere to background ratio (SBR). Results: The use of a 68Ge phantom allowed reducing the inter-scanner variability among different scanners from 74.0% to 20.5% in BAC and from 63.3% to 17.4% in SBR compared to using the 18F phantom. The CTQ criteria were fulfilled at first round in 100% and 28% of PET scanners with 68Ge and 18F respectively. Conclusions: The 68Ge phantom proved a reliable tool for PET scanner qualification, able to significantly reduce the potential sources of error while increasing the reproducibility of PET derived quantitative parameter measurement.
AB - Purpose: The quantitative assessment of Positron Emission Tomography (PET) scans using standardized uptake value and derived parameters proved to be superior to traditional qualitative assessment in several retrospective or mono-centric prospective reports. Since different scanners give different quantitative readings, a program for clinical trial qualification (CTQ) is mandatory to guarantee a reliable and reproducible use of quantitative PET in prospective multi-centre clinical trials and in every-day clinical life. Methods: We set up, under the auspices of Italian Foundation on Lymphoma (FIL), a CTQ program consisting of the PET/CT scan acquisition and analysis of 18F and 68Ge NEMA/IEC image quality phantoms for the reduction of inter-scanner variability. Variability was estimated on background activity concentration (BAC) and sphere to background ratio (SBR). Results: The use of a 68Ge phantom allowed reducing the inter-scanner variability among different scanners from 74.0% to 20.5% in BAC and from 63.3% to 17.4% in SBR compared to using the 18F phantom. The CTQ criteria were fulfilled at first round in 100% and 28% of PET scanners with 68Ge and 18F respectively. Conclusions: The 68Ge phantom proved a reliable tool for PET scanner qualification, able to significantly reduce the potential sources of error while increasing the reproducibility of PET derived quantitative parameter measurement.
KW - Clinical trials
KW - Lymphoma
KW - Positron emission tomography
KW - Quantitative imaging
UR - http://www.scopus.com/inward/record.url?scp=84964579687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84964579687&partnerID=8YFLogxK
U2 - 10.1016/j.ejmp.2016.04.004
DO - 10.1016/j.ejmp.2016.04.004
M3 - Article
AN - SCOPUS:84964579687
VL - 32
SP - 651
EP - 656
JO - Physica Medica
JF - Physica Medica
SN - 1120-1797
IS - 5
ER -