The Suppressive Attitude of Inflammatory Monocytes in Antiviral Antibody Responses

Eleonora Sala, Mirela Kuka

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory monocytes play important functions in antiviral immune responses, including release of inflammatory cytokines and antigen presentation to T lymphocytes. Depending on the pathological context, these functions might translate into beneficial or detrimental effects in the resolution of the disease. Recent literature has highlighted a role for inflammatory monocytes also in direct suppression of B cell responses. In this review, we will briefly discuss research showing the relationship between inflammatory monocytes and B lymphocytes, its functional consequences on antiviral antibody responses, and possible implications in the design of future vaccination strategies.

Original languageEnglish
Pages (from-to)327-333
Number of pages7
JournalViral Immunology
Volume33
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • B cell
  • humoral immunity
  • inflammatory monocytes
  • nitric oxide
  • suppression

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Virology

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