The surgical treatment of lung cancer in patients with previous lymphoproliferative disorders: A historical cohort study

G. Melloni, P. Muriana, S. Sestini, A. Bandiera, A. Carretta, P. Ciriaco, G. Calori, G. Muriana, P. Zannini

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: We undertook a historical cohort study to compare, in terms of morbidity, mortality and long-term survival associated with lung cancer resection, a group of patients with previous lymphoproliferative disorders and a group without a hematological history. Methods: We identified 29 patients with a previous lymphoproliferative disorder who underwent lung cancer resection. These subjects (Group-A) were matched with 87 patients without a hematological history who underwent pulmonary resection during the same period (Group-B). Results: We found no significant difference between the two groups in length of hospitalization, comorbidities, spirometric parameters, type of surgery, histology, neoadjuvant chemotherapy, morbidity, mortality, median survival (Group-A = 37 months; Group-B = 52 months) and 5-year survival (Group-A = 37%; Group-B = 42%). The mean age of Group-A patients was significantly lower than that of Group-B patients (62 vs 66 years; p = 0.024). Group-A patients had a well differentiated lung cancer more frequently than Group-B patients (p = 0.001). Group-A patients had transitory bacteraemies more frequently than Group-B patients (p = 0.005). Multivariate Cox regression analysis showed that age (p = 0.01) and lung cancer stage (p = 0.04) were significantly associated with survival. Conclusions: Patients with lymphoproliferative disorders had a lower age and more differentiated lung cancers than those without lymphoproliferative disorders. Patients with lymphoproliferative disorders and those without a hematological history had similar morbidity, mortality and long-term survival after pulmonary resection. Distinguishing patients with and without a lymphoproliferative disorder seems to be of limited value in the decision-making process of evaluating the indications for surgical treatment of lung cancer.

Original languageEnglish
Pages (from-to)711-717
Number of pages7
JournalEuropean Journal of Surgical Oncology
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Lung cancer
  • Lymphoproliferative disorders
  • Surgery

ASJC Scopus subject areas

  • Oncology
  • Surgery

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