The synapsins and the regulation of synaptic function

Martin Bähler, Fabio Benfenati, Flavia Valtorta, Paul Greengard

Research output: Contribution to journalArticle

Abstract

Synapsins I and II are a family of synaptic vesicle-associated phosphoproteins involved in the short-term regulation of neurotransmitter release. In this review, we discuss a working model for the molecular mechanisms by which the synapsins act. We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin II.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalBioEssays
Volume12
Issue number6
Publication statusPublished - 1990

Fingerprint

Synapsins
molecular models
phosphoproteins
neurotransmitters
microfilaments
functional properties
signal transduction
phosphorylation
nerve tissue
Synaptic Vesicles
Signal transduction
Phosphorylation
Molecular Models
synaptic vesicles
Phosphoproteins
Presynaptic Terminals
Actin Cytoskeleton
Neurotransmitter Agents
Actins
Signal Transduction

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Bähler, M., Benfenati, F., Valtorta, F., & Greengard, P. (1990). The synapsins and the regulation of synaptic function. BioEssays, 12(6), 259-263.

The synapsins and the regulation of synaptic function. / Bähler, Martin; Benfenati, Fabio; Valtorta, Flavia; Greengard, Paul.

In: BioEssays, Vol. 12, No. 6, 1990, p. 259-263.

Research output: Contribution to journalArticle

Bähler, M, Benfenati, F, Valtorta, F & Greengard, P 1990, 'The synapsins and the regulation of synaptic function', BioEssays, vol. 12, no. 6, pp. 259-263.
Bähler M, Benfenati F, Valtorta F, Greengard P. The synapsins and the regulation of synaptic function. BioEssays. 1990;12(6):259-263.
Bähler, Martin ; Benfenati, Fabio ; Valtorta, Flavia ; Greengard, Paul. / The synapsins and the regulation of synaptic function. In: BioEssays. 1990 ; Vol. 12, No. 6. pp. 259-263.
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