The synapsins and the regulation of synaptic function

Martin Bähler, Fabio Benfenati, Flavia Valtorta, Paul Greengard

Research output: Contribution to journalArticlepeer-review

Abstract

Synapsins I and II are a family of synaptic vesicle-associated phosphoproteins involved in the short-term regulation of neurotransmitter release. In this review, we discuss a working model for the molecular mechanisms by which the synapsins act. We propose that synapsin I links synaptic vesicles to actin filaments in the presynaptic nerve terminal and that these interactions are modulated by the reversible phosphorylation of synapsin I through various signal transduction pathways. The high degree of homology between the synapsins suggests that some of the functional properties of synapsin I are also shared by synapsin II.

Original languageEnglish
Pages (from-to)259-263
Number of pages5
JournalBioEssays
Volume12
Issue number6
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

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