Abstract
The transcription factors, thyroid transcription factor 1 (TTF-1) and Pax 8, play a pivotal role in the transcriptional regulation of the thyroid differentiation marker genes and in the differentiation of the thyroid follicular cells. They have a very restricted tissue distribution, and the thyrocyte is the only cell type with the simultaneous expression of these factors. Here we show that TTF-1 and Pax 8 cooperatively activate their target genes and that their synergistic activity requires the cross-talk between enhancer and gene promoter. We have characterized the cis and trans requirements of the TTF1/Pax 8 synergistic activity on the thyroperoxidase gene. We show that their synergy is also important for thyroglobulin gene transcription.
Original language | English |
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Pages (from-to) | 837-846 |
Number of pages | 10 |
Journal | Molecular Endocrinology |
Volume | 16 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2002 |
ASJC Scopus subject areas
- Molecular Biology
- Endocrinology, Diabetes and Metabolism