The system epilepsies: A pathophysiological hypothesis

Giuliano Avanzini, Paolo Manganotti, Stefano Meletti, Solomon L. Moshé, Ferruccio Panzica, Peter Wolf, Giuseppe Capovilla

Research output: Contribution to journalArticle


We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

Original languageEnglish
Pages (from-to)771-778
Number of pages8
Issue number5
Publication statusPublished - May 2012



  • Cortico-cortical connections
  • Focal epilepsies
  • Generalized epilepsies
  • Neural systems
  • Thalamo-cortical systems

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Avanzini, G., Manganotti, P., Meletti, S., Moshé, S. L., Panzica, F., Wolf, P., & Capovilla, G. (2012). The system epilepsies: A pathophysiological hypothesis. Epilepsia, 53(5), 771-778.