Abstract
We recently postulated that susceptibility to HIV infection and progression of HIV-infected individuals to AIDS is controlled by cytokines that regulate 2 functionally distinct subsets of T helper (TH) lymphocytes. These subsets are TH1, which mainly enhance cell-mediated immunity and are regulated by type 1 cytokines. and TH2, which mainly augment antibody production and are regulated by type 2 cytokines. HIV-seronegative individuals exposed to HIV may exhibit strong HIV-specific T cell-mediated immunity, since both HIV-specific T helper and T cytotoxic lymphocytes are activated in the absence of seroconversion and disease. Additionally, during progression of HIV-seropositive individuals to AIDS. a decline is observed in type 1 cytokines as well as an increase in the production of type 2 cytokines by HIV-positive peripheral blood mononuclear cells stimulated in vitro. The type 1 to type 2 switch is predictive for the following clinically relevant events: (a) reduction in CD4+ cell counts; (b) time to diagnosis of AIDS; and (c) time to death. The manipulation of the immune response to induce and strengthen HIV-specific immunity may thus be useful in the management of HIV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 95-101 |
| Number of pages | 7 |
| Journal | Clinical Immunotherapeutics |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Immunology and Allergy
- Pharmacology (medical)
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The T Helper Cell Shift in AIDS : Significance for Pharmacotherapy. / Clerici, Mario; Shearer, Gene M.
In: Clinical Immunotherapeutics, Vol. 3, No. 2, 1995, p. 95-101.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The T Helper Cell Shift in AIDS
T2 - Significance for Pharmacotherapy
AU - Clerici, Mario
AU - Shearer, Gene M.
PY - 1995
Y1 - 1995
N2 - We recently postulated that susceptibility to HIV infection and progression of HIV-infected individuals to AIDS is controlled by cytokines that regulate 2 functionally distinct subsets of T helper (TH) lymphocytes. These subsets are TH1, which mainly enhance cell-mediated immunity and are regulated by type 1 cytokines. and TH2, which mainly augment antibody production and are regulated by type 2 cytokines. HIV-seronegative individuals exposed to HIV may exhibit strong HIV-specific T cell-mediated immunity, since both HIV-specific T helper and T cytotoxic lymphocytes are activated in the absence of seroconversion and disease. Additionally, during progression of HIV-seropositive individuals to AIDS. a decline is observed in type 1 cytokines as well as an increase in the production of type 2 cytokines by HIV-positive peripheral blood mononuclear cells stimulated in vitro. The type 1 to type 2 switch is predictive for the following clinically relevant events: (a) reduction in CD4+ cell counts; (b) time to diagnosis of AIDS; and (c) time to death. The manipulation of the immune response to induce and strengthen HIV-specific immunity may thus be useful in the management of HIV infection.
AB - We recently postulated that susceptibility to HIV infection and progression of HIV-infected individuals to AIDS is controlled by cytokines that regulate 2 functionally distinct subsets of T helper (TH) lymphocytes. These subsets are TH1, which mainly enhance cell-mediated immunity and are regulated by type 1 cytokines. and TH2, which mainly augment antibody production and are regulated by type 2 cytokines. HIV-seronegative individuals exposed to HIV may exhibit strong HIV-specific T cell-mediated immunity, since both HIV-specific T helper and T cytotoxic lymphocytes are activated in the absence of seroconversion and disease. Additionally, during progression of HIV-seropositive individuals to AIDS. a decline is observed in type 1 cytokines as well as an increase in the production of type 2 cytokines by HIV-positive peripheral blood mononuclear cells stimulated in vitro. The type 1 to type 2 switch is predictive for the following clinically relevant events: (a) reduction in CD4+ cell counts; (b) time to diagnosis of AIDS; and (c) time to death. The manipulation of the immune response to induce and strengthen HIV-specific immunity may thus be useful in the management of HIV infection.
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U2 - 10.1007/BF03259271
DO - 10.1007/BF03259271
M3 - Article
VL - 3
SP - 95
EP - 101
JO - BioDrugs
JF - BioDrugs
SN - 1172-7039
IS - 2
ER -