Abstract
Current guidelines on antihypertensive treatment emphasize the importance of combination drug treatment for achieving a full blood pressure control. The TALENT Study, involving more than 400 high-risk hypertensive patients, aimed to evaluate the efficacy and safety profile of nifedipine gastrointestinal therapeutic system (GITS) 20 mg/telmisartan 80 mg combination, as compared to the single monotherapies. After 8 weeks, ambulatory blood pressure values were significantly more reduced by the combination treatment than by single monotherapies. These potentiated blood-pressure-lowering effects were mirrored by a higher trough-to-peak ratio and smoothness index. They were also accompanied by: i) significantly greater blood pressure (particularly systolic) control; ii) a greater ability of combination drug treatment to achieve a controlled blood pressure at a time earlier than that found in single monotherapies; and iii) a better side-effects profile.
| Original language | English |
|---|---|
| Pages (from-to) | 607-611 |
| Number of pages | 5 |
| Journal | Expert Opinion on Pharmacotherapy |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Mar 2012 |
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Keywords
- Ambulatory blood pressure
- Blood pressure control
- Combination drug treatment
- Hypertension
- Monotherapy
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
Cite this
The talent study. / Grassi, Guido.
In: Expert Opinion on Pharmacotherapy, Vol. 13, No. 4, 03.2012, p. 607-611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The talent study
AU - Grassi, Guido
PY - 2012/3
Y1 - 2012/3
N2 - Current guidelines on antihypertensive treatment emphasize the importance of combination drug treatment for achieving a full blood pressure control. The TALENT Study, involving more than 400 high-risk hypertensive patients, aimed to evaluate the efficacy and safety profile of nifedipine gastrointestinal therapeutic system (GITS) 20 mg/telmisartan 80 mg combination, as compared to the single monotherapies. After 8 weeks, ambulatory blood pressure values were significantly more reduced by the combination treatment than by single monotherapies. These potentiated blood-pressure-lowering effects were mirrored by a higher trough-to-peak ratio and smoothness index. They were also accompanied by: i) significantly greater blood pressure (particularly systolic) control; ii) a greater ability of combination drug treatment to achieve a controlled blood pressure at a time earlier than that found in single monotherapies; and iii) a better side-effects profile.
AB - Current guidelines on antihypertensive treatment emphasize the importance of combination drug treatment for achieving a full blood pressure control. The TALENT Study, involving more than 400 high-risk hypertensive patients, aimed to evaluate the efficacy and safety profile of nifedipine gastrointestinal therapeutic system (GITS) 20 mg/telmisartan 80 mg combination, as compared to the single monotherapies. After 8 weeks, ambulatory blood pressure values were significantly more reduced by the combination treatment than by single monotherapies. These potentiated blood-pressure-lowering effects were mirrored by a higher trough-to-peak ratio and smoothness index. They were also accompanied by: i) significantly greater blood pressure (particularly systolic) control; ii) a greater ability of combination drug treatment to achieve a controlled blood pressure at a time earlier than that found in single monotherapies; and iii) a better side-effects profile.
KW - Ambulatory blood pressure
KW - Blood pressure control
KW - Combination drug treatment
KW - Hypertension
KW - Monotherapy
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UR - http://www.scopus.com/inward/citedby.url?scp=84857325203&partnerID=8YFLogxK
U2 - 10.1517/14656566.2012.658772
DO - 10.1517/14656566.2012.658772
M3 - Article
C2 - 22332938
AN - SCOPUS:84857325203
VL - 13
SP - 607
EP - 611
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
SN - 1465-6566
IS - 4
ER -