The Tcl1 oncogene defines secondary hair germ cells differentiation at catagen-telogen transition and affects stem-cell marker CD34 expression

G. Ragone, A. Bresin, F. Piermarini, C. Lazzeri, M. C. Picchio, D. Remotti, S. M. Kang, M. D. Cooper, C. M. Croce, M. G. Narducci, G. Russo

Research output: Contribution to journalArticlepeer-review

Abstract

Overexpression of the TCL1 gene family plays a role in the onset of T-cell leukemias in mice and in humans. The Tcl1 gene is tightly regulated during early embryogenesis in which it participates in embryonic stem (ES)-cells proliferation and during lymphoid differentiation. Here, we provide evidences that Tcl1 is also important in mouse hair follicle (HF) and skin homeostasis. We found that Tcl1-/- adult mice exhibit hair loss, leading to alopecia with extensive skin lesions. By analysing Tcl1 expression in the wild-type (wt) skin through different stages of hair differentiation, we observe high levels in the secondary hair germ (HG) cells and hair bulges, during early anagen and catagen-telogen transition phases. The loss of Tcl1 does not result in apparent skin morphological defects during embryonic development and at birth, but its absence causes a reduction of proliferation in anagen HFs. Importantly, we show the that absence of Tcl1 induces a significant loss of the stem-cell marker CD34 (but not α6-integrin) expression in the bulge cells, which is necessary to maintain stem-cell characteristics. Therefore, our findings indicate that Tcl1 gene(s) might have important roles in hair formation, by its involvement in cycling and self-renewal of transient amplifying (TA) and stem-cell (SC) populations.

Original languageEnglish
Pages (from-to)1329-1338
Number of pages10
JournalOncogene
Volume28
Issue number10
DOIs
Publication statusPublished - Mar 12 2009

Keywords

  • Bulge cells
  • Hair follicle
  • Secondary hair germ cells
  • Stem-cells
  • Tcl1
  • Transient-amplifying cells

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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