The technologically integrated oncosimulator: Combining multiscale cancer modeling with information technology in the in silico oncology context

Georgios Stamatakos, Dimitra Dionysiou, Aran Lunzer, Robert Belleman, Eleni Kolokotroni, Eleni Georgiadi, Marius Erdt, Juliusz Pukacki, Stefan Rueping, Stavroula Giatili, Alberto Donofrio, Stelios Sfakianakis, Kostas Marias, Christine Desmedt, Manolis Tsiknakis, Norbert Graf

Research output: Contribution to journalArticlepeer-review

Abstract

This paper outlines the major components and function of the technologically integrated oncosimulator developed primarily within the Advancing Clinico Genomic Trials on Cancer (ACGT) project. The Oncosimulator is defined as an information technology system simulating in vivo tumor response to therapeutic modalities within the clinical trial context. Chemotherapy in the neoadjuvant setting, according to two real clinical trials concerning nephroblastoma and breast cancer, has been considered. The spatiotemporal simulation module embedded in the Oncosimulator is based on the multiscale, predominantly top-down, discrete entity-discrete event cancer simulation technique developed by the In Silico Oncology Group, National Technical University of Athens. The technology modules include multiscale data handling, image processing, invocation of code execution via a spreadsheet-inspired environment portal, execution of the code on the grid, and the visualization of the predictions. A refining scenario for the eventual coupling of the oncosimulator with immunological models is also presented. Parameter values have been adapted to multiscale clinical trial data in a consistent way, thus supporting the predictive potential of the oncosimulator. Indicative results demonstrating various aspects of the clinical adaptation and validation process are presented. Completion of these processes is expected to pave the way for the clinical translation of the system.

Original languageEnglish
Article number6617658
Pages (from-to)840-854
Number of pages15
JournalIEEE Journal of Biomedical and Health Informatics
Volume18
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Advancing Clinico Genomic Trials on Cancer (ACGT) project
  • breast cancer
  • in silico medicine
  • in silico oncology
  • multiscale cancer modeling
  • nephroblastoma
  • oncosimulator
  • Virtual Physiological Human (VPH)

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Health Information Management
  • Medicine(all)

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