The TGF-β superfamily in dendritic cell biology

Pascal Seeger, Tiziana Musso, Silvano Sozzani

Research output: Contribution to journalArticlepeer-review


The TGF-β superfamily consists of a large group of pleiotropic cytokines that are involved in the regulation of many developmental, physiological and pathological processes. Dendritic cells are antigen-presenting cells that play a key role in innate and adaptive immune responses. Dendritic cells have a complex relationship with the TGF-β cytokine superfamily being both source and targets for many of these cytokines. Some TGF-β family members are expressed by dendritic cells and modulate immune responses, for instance through the induction of T cell polarization. Others play a crucial role in the development and function of the different dendritic cell subsets. This review summarizes the current knowledge on the role of TGF-β family cytokines in dendritic cell biology, focusing on TGF-β as well as on other, less characterized, members of these important immune mediators.

Original languageEnglish
Pages (from-to)647-657
Number of pages11
JournalCytokine and Growth Factor Reviews
Issue number6
Publication statusPublished - Dec 1 2015


  • Activin A
  • Bone morphogenetic protein
  • Dendritic cells
  • NK cells
  • T cells
  • TGF-β

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)


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