The third ventricle of the human fetal brain

Normative data and pathologic correlation. A 3D transvaginal neurosonography study

Roee Birnbaum, Stefano Parodi, Gloria Donarini, Gabriella Meccariello, Ezio Fulcheri, Dario Paladini

Research output: Contribution to journalArticle

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Abstract

Objective: The objective of the study are to describe (a) the technical aspects and (b) the anatomical boundaries of the fetal third ventricle (3V) on the midsagittal sonographic view and to assess (c) different biometric parameters in normal and abnormal fetuses and (d) and their reproducibility. Methods: This study included 67 normal and 50 CNS anomalies fetuses which include (1) obstructive severe ventriculomegaly (SVM; atrial width ≥ 15 mm), (2) moderate ventriculomegaly (10-14.9 mm), and (3) corpus callosum agenesis (ACC). All underwent transvaginal 3D neurosonography of the midsagittal view of the 3V. The following parameters were measured: area, perimeter, craniocaudal and anteroposterior (AP) diameters, interthalamic adhesion diameter (ITAD), wedge angle, and the ratio between the last 2 variables (ITAD/WA). Repeatability was also assessed. Results: The ITAD and the ITAD/WA are significantly different between normal fetuses and the SVM (P ≤.001). Interthalamic adhesion diameter of ≤7.1 mm is able to identify SVM with 98.6% accuracy (CI: 0.92-0.99). In ACC cases, the AP diameter is significantly shorter than both normal fetuses and ventriculomegaly. Intraobserver/interobserver reliability was good for most variables. Conclusions: Transvaginal neurosonography enables visualization of the normal and abnormal fetal third ventricle. An ITAD <7.1 identifies aqueductal stenosis as the likely etiology of severe ventriculomegaly with an accuracy of 98.6%.

Original languageEnglish
Pages (from-to)664-672
Number of pages9
JournalPrenatal Diagnosis
Volume38
Issue number9
DOIs
Publication statusPublished - Aug 1 2018

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Third Ventricle
Fetus
Brain
Agenesis of Corpus Callosum
Hydrocephalus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Genetics(clinical)

Cite this

The third ventricle of the human fetal brain : Normative data and pathologic correlation. A 3D transvaginal neurosonography study. / Birnbaum, Roee; Parodi, Stefano; Donarini, Gloria; Meccariello, Gabriella; Fulcheri, Ezio; Paladini, Dario.

In: Prenatal Diagnosis, Vol. 38, No. 9, 01.08.2018, p. 664-672.

Research output: Contribution to journalArticle

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