TY - JOUR
T1 - The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity
AU - Cantoni, Claudia
AU - Ponassi, Marco
AU - Biassoni, Roberto
AU - Conte, Romana
AU - Spallarossa, Andrea
AU - Moretta, Alessandro
AU - Moretta, Lorenzo
AU - Bolognesi, Martino
AU - Bordo, Domenico
PY - 2003/6
Y1 - 2003/6
N2 - Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 Å crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
AB - Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell activation depends on a fine balance between inhibitory and activating receptors. NKp44 is a cytotoxicity activating receptor composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. The 2.2 Å crystal structure shows that the NKp44 Ig domain forms a saddle-shaped dimer, where a charged surface groove protrudes from the core structure in each subunit. NKp44 Ig domain disulfide bridge topology defines a new Ig structural subfamily. The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive.
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U2 - 10.1016/S0969-2126(03)00095-9
DO - 10.1016/S0969-2126(03)00095-9
M3 - Article
C2 - 12791260
AN - SCOPUS:0043102633
VL - 11
SP - 725
EP - 734
JO - Structure with Folding & design
JF - Structure with Folding & design
SN - 0969-2126
IS - 6
ER -