The THRombolysis and STatins (THRaST) study

Manuel Cappellari, Paolo Bovi, Giuseppe Moretto, Andrea Zini, Patrizia Nencini, Maria Sessa, Mauro Furlan, Alessandro Pezzini, Giovanni Orlandi, Maurizio Paciaroni, Tiziana Tassinari, Gaetano Procaccianti, Vincenzo Di Lazzaro, Luigi Bettoni, Carlo Gandolfo, Giorgio Silvestrelli, Maurizia Rasura, Giuseppe Martini, Maurizio Melis, Maria Vittoria CalloniFabio Chiodo-Grandi, Simone Beretta, Maria Guarino, Maria Concetta Altavista, Simona Marcheselli, Giampiero Galletti, Laura Adobbati, Massimo Del Sette, Armando Mancini, Daniele Orrico, Serena Monaco, Anna Cavallini, Rossella Sciolla, Francesco Federico, Umberto Scoditti, Fabio Brusaferri, Claudio Grassa, Luigi Specchio, Maria Roberta Bongioanni, Marco Sparaco, Mauro Zampolini, Gabriele Greco, Rinaldo Colombo, Bruno Passarella, Alessandro Adami, Domenico Consoli, Danilo Toni

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis. Methods: Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death. Results: Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.26-2.25; p <0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p <0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007). Conclusion: Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.

Original languageEnglish
Pages (from-to)655-661
Number of pages7
JournalNeurology
Volume80
Issue number7
DOIs
Publication statusPublished - Feb 12 2013

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Stroke
Nervous System
Odds Ratio
Confidence Intervals
Outcome Assessment (Health Care)
Cerebral Hemorrhage
Multicenter Studies
Multivariate Analysis
Confidence Interval
Safety

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Cappellari, M., Bovi, P., Moretto, G., Zini, A., Nencini, P., Sessa, M., ... Toni, D. (2013). The THRombolysis and STatins (THRaST) study. Neurology, 80(7), 655-661. https://doi.org/10.1212/WNL.0b013e318281cc83

The THRombolysis and STatins (THRaST) study. / Cappellari, Manuel; Bovi, Paolo; Moretto, Giuseppe; Zini, Andrea; Nencini, Patrizia; Sessa, Maria; Furlan, Mauro; Pezzini, Alessandro; Orlandi, Giovanni; Paciaroni, Maurizio; Tassinari, Tiziana; Procaccianti, Gaetano; Di Lazzaro, Vincenzo; Bettoni, Luigi; Gandolfo, Carlo; Silvestrelli, Giorgio; Rasura, Maurizia; Martini, Giuseppe; Melis, Maurizio; Calloni, Maria Vittoria; Chiodo-Grandi, Fabio; Beretta, Simone; Guarino, Maria; Altavista, Maria Concetta; Marcheselli, Simona; Galletti, Giampiero; Adobbati, Laura; Del Sette, Massimo; Mancini, Armando; Orrico, Daniele; Monaco, Serena; Cavallini, Anna; Sciolla, Rossella; Federico, Francesco; Scoditti, Umberto; Brusaferri, Fabio; Grassa, Claudio; Specchio, Luigi; Bongioanni, Maria Roberta; Sparaco, Marco; Zampolini, Mauro; Greco, Gabriele; Colombo, Rinaldo; Passarella, Bruno; Adami, Alessandro; Consoli, Domenico; Toni, Danilo.

In: Neurology, Vol. 80, No. 7, 12.02.2013, p. 655-661.

Research output: Contribution to journalArticle

Cappellari, M, Bovi, P, Moretto, G, Zini, A, Nencini, P, Sessa, M, Furlan, M, Pezzini, A, Orlandi, G, Paciaroni, M, Tassinari, T, Procaccianti, G, Di Lazzaro, V, Bettoni, L, Gandolfo, C, Silvestrelli, G, Rasura, M, Martini, G, Melis, M, Calloni, MV, Chiodo-Grandi, F, Beretta, S, Guarino, M, Altavista, MC, Marcheselli, S, Galletti, G, Adobbati, L, Del Sette, M, Mancini, A, Orrico, D, Monaco, S, Cavallini, A, Sciolla, R, Federico, F, Scoditti, U, Brusaferri, F, Grassa, C, Specchio, L, Bongioanni, MR, Sparaco, M, Zampolini, M, Greco, G, Colombo, R, Passarella, B, Adami, A, Consoli, D & Toni, D 2013, 'The THRombolysis and STatins (THRaST) study', Neurology, vol. 80, no. 7, pp. 655-661. https://doi.org/10.1212/WNL.0b013e318281cc83
Cappellari M, Bovi P, Moretto G, Zini A, Nencini P, Sessa M et al. The THRombolysis and STatins (THRaST) study. Neurology. 2013 Feb 12;80(7):655-661. https://doi.org/10.1212/WNL.0b013e318281cc83
Cappellari, Manuel ; Bovi, Paolo ; Moretto, Giuseppe ; Zini, Andrea ; Nencini, Patrizia ; Sessa, Maria ; Furlan, Mauro ; Pezzini, Alessandro ; Orlandi, Giovanni ; Paciaroni, Maurizio ; Tassinari, Tiziana ; Procaccianti, Gaetano ; Di Lazzaro, Vincenzo ; Bettoni, Luigi ; Gandolfo, Carlo ; Silvestrelli, Giorgio ; Rasura, Maurizia ; Martini, Giuseppe ; Melis, Maurizio ; Calloni, Maria Vittoria ; Chiodo-Grandi, Fabio ; Beretta, Simone ; Guarino, Maria ; Altavista, Maria Concetta ; Marcheselli, Simona ; Galletti, Giampiero ; Adobbati, Laura ; Del Sette, Massimo ; Mancini, Armando ; Orrico, Daniele ; Monaco, Serena ; Cavallini, Anna ; Sciolla, Rossella ; Federico, Francesco ; Scoditti, Umberto ; Brusaferri, Fabio ; Grassa, Claudio ; Specchio, Luigi ; Bongioanni, Maria Roberta ; Sparaco, Marco ; Zampolini, Mauro ; Greco, Gabriele ; Colombo, Rinaldo ; Passarella, Bruno ; Adami, Alessandro ; Consoli, Domenico ; Toni, Danilo. / The THRombolysis and STatins (THRaST) study. In: Neurology. 2013 ; Vol. 80, No. 7. pp. 655-661.
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abstract = "Objective: To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis. Methods: Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death. Results: Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95{\%} confidence interval [CI] 1.26-2.25; p <0.001), major neurologic improvement (OR 1.43, 95{\%} CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95{\%} CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95{\%} CI 0.19-0.53; p <0.001) and death (OR 0.48, 95{\%} CI 0.28-0.82; p = 0.007). Conclusion: Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.",
author = "Manuel Cappellari and Paolo Bovi and Giuseppe Moretto and Andrea Zini and Patrizia Nencini and Maria Sessa and Mauro Furlan and Alessandro Pezzini and Giovanni Orlandi and Maurizio Paciaroni and Tiziana Tassinari and Gaetano Procaccianti and {Di Lazzaro}, Vincenzo and Luigi Bettoni and Carlo Gandolfo and Giorgio Silvestrelli and Maurizia Rasura and Giuseppe Martini and Maurizio Melis and Calloni, {Maria Vittoria} and Fabio Chiodo-Grandi and Simone Beretta and Maria Guarino and Altavista, {Maria Concetta} and Simona Marcheselli and Giampiero Galletti and Laura Adobbati and {Del Sette}, Massimo and Armando Mancini and Daniele Orrico and Serena Monaco and Anna Cavallini and Rossella Sciolla and Francesco Federico and Umberto Scoditti and Fabio Brusaferri and Claudio Grassa and Luigi Specchio and Bongioanni, {Maria Roberta} and Marco Sparaco and Mauro Zampolini and Gabriele Greco and Rinaldo Colombo and Bruno Passarella and Alessandro Adami and Domenico Consoli and Danilo Toni",
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T1 - The THRombolysis and STatins (THRaST) study

AU - Cappellari, Manuel

AU - Bovi, Paolo

AU - Moretto, Giuseppe

AU - Zini, Andrea

AU - Nencini, Patrizia

AU - Sessa, Maria

AU - Furlan, Mauro

AU - Pezzini, Alessandro

AU - Orlandi, Giovanni

AU - Paciaroni, Maurizio

AU - Tassinari, Tiziana

AU - Procaccianti, Gaetano

AU - Di Lazzaro, Vincenzo

AU - Bettoni, Luigi

AU - Gandolfo, Carlo

AU - Silvestrelli, Giorgio

AU - Rasura, Maurizia

AU - Martini, Giuseppe

AU - Melis, Maurizio

AU - Calloni, Maria Vittoria

AU - Chiodo-Grandi, Fabio

AU - Beretta, Simone

AU - Guarino, Maria

AU - Altavista, Maria Concetta

AU - Marcheselli, Simona

AU - Galletti, Giampiero

AU - Adobbati, Laura

AU - Del Sette, Massimo

AU - Mancini, Armando

AU - Orrico, Daniele

AU - Monaco, Serena

AU - Cavallini, Anna

AU - Sciolla, Rossella

AU - Federico, Francesco

AU - Scoditti, Umberto

AU - Brusaferri, Fabio

AU - Grassa, Claudio

AU - Specchio, Luigi

AU - Bongioanni, Maria Roberta

AU - Sparaco, Marco

AU - Zampolini, Mauro

AU - Greco, Gabriele

AU - Colombo, Rinaldo

AU - Passarella, Bruno

AU - Adami, Alessandro

AU - Consoli, Domenico

AU - Toni, Danilo

PY - 2013/2/12

Y1 - 2013/2/12

N2 - Objective: To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis. Methods: Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death. Results: Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.26-2.25; p <0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p <0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007). Conclusion: Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.

AB - Objective: To assess the impact on stroke outcome of statin use in the acute phase after IV thrombolysis. Methods: Multicenter study on prospectively collected data of 2,072 stroke patients treated with IV thrombolysis. Outcome measures of efficacy were neurologic improvement (NIH Stroke Scale [NIHSS] ≤ 4 points from baseline or NIHSS = 0) and major neurologic improvement (NIHSS ≤ 8 points from baseline or NIHSS = 0) at 7 days and favorable (modified Rankin Scale [mRS] ≤ 2) and excellent functional outcome (mRS ≤ 1) at 3 months. Outcome measures of safety were 7-day neurologic deterioration (NIHSS ≥ 4 points from baseline or death), symptomatic intracerebral hemorrhage type 2 with NIHSS ≥ 4 points from baseline or death within 36 hours, and 3-month death. Results: Adjusted multivariate analysis showed that statin use in the acute phase was associated with neurologic improvement (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.26-2.25; p <0.001), major neurologic improvement (OR 1.43, 95% CI 1.11-1.85; p = 0.006), favorable functional outcome (OR 1.63, 95% CI 1.18-2.26; p = 0.003), and a reduced risk of neurologic deterioration (OR: 0.31, 95% CI 0.19-0.53; p <0.001) and death (OR 0.48, 95% CI 0.28-0.82; p = 0.007). Conclusion: Statin use in the acute phase of stroke after IV thrombolysis may positively influence short- and long-term outcome.

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