TY - JOUR
T1 - The time course of diagnostic delay in inflammatory bowel disease over the last sixty years
T2 - An Italian multicentre study
AU - Cantoro, Laura
AU - Di Sabatino, Antonio
AU - Papi, Claudio
AU - Margagnoni, Giovanna
AU - Ardizzone, Sandro
AU - Giuffrida, Paolo
AU - Giannarelli, Diana
AU - Massari, Alessandro
AU - Monterubbianesi, Rita
AU - Lenti, Marco Vincenzo
AU - Corazza, Gino Roberto
AU - Kohn, Anna
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background and Aims: Inflammatory bowel disease [IBD] patients are still under-diagnosed or diagnosed with serious delay. We examined whether diagnostic delay [DD] in IBD has changed over the last 60 years, and explored the risk factors of longer DD. Methods: In total, 3392 IBD patients recorded in the registry of four IBD Italian centres were divided according to the year of diagnosis into a historical cohort [HC: 1955–84] and modern cohort [MC: 1985–2014]. DD, i.e. time lapse between onset of symptoms indicative of IBD and definitive diagnosis, was divided into four sub-periods [0–6, 7–12, 13–24, >24 months], which were correlated with age and disease location/behaviour at diagnosis. Results: Median DD in IBD was 3.0 months, it was significantly [P < 0.0001] higher in Crohn's disease [CD] [7.1 months] than in ulcerative colitis [UC] [2.0 months], and did not differ either between the HC and the MC or over the last three decades. However, the proportion of patients with a DD>24 months was significantly [P < 0.0001] higher in the HC [26.0%] than in the MC [18.2%], and the same trend was evident over the last three decades [1985–94: 19.9%; 1995–2004: 16.4%; 2005–14: 13.9%; P = 0.04]. At logistic regression analysis, age at diagnosis >40 years (CD: odds ratio 1.73, 95% confidence interval [CI] 1.31–2.28, P < 0.0001; UC: 1.41, 95% CI 1.02–1.96, P = 0.04) and complicated disease at CD diagnosis [1.39, 95% CI 1.06–1.82, P = 0.02] were independently associated with a DD>24 months. Conclusions: DD duration has not changed over the last 60 years in Italy, but the number of IBD patients with a longer DD significantly decreased. Older age at diagnosis and a complicated disease at CD diagnosis are risk factors for longer DD.
AB - Background and Aims: Inflammatory bowel disease [IBD] patients are still under-diagnosed or diagnosed with serious delay. We examined whether diagnostic delay [DD] in IBD has changed over the last 60 years, and explored the risk factors of longer DD. Methods: In total, 3392 IBD patients recorded in the registry of four IBD Italian centres were divided according to the year of diagnosis into a historical cohort [HC: 1955–84] and modern cohort [MC: 1985–2014]. DD, i.e. time lapse between onset of symptoms indicative of IBD and definitive diagnosis, was divided into four sub-periods [0–6, 7–12, 13–24, >24 months], which were correlated with age and disease location/behaviour at diagnosis. Results: Median DD in IBD was 3.0 months, it was significantly [P < 0.0001] higher in Crohn's disease [CD] [7.1 months] than in ulcerative colitis [UC] [2.0 months], and did not differ either between the HC and the MC or over the last three decades. However, the proportion of patients with a DD>24 months was significantly [P < 0.0001] higher in the HC [26.0%] than in the MC [18.2%], and the same trend was evident over the last three decades [1985–94: 19.9%; 1995–2004: 16.4%; 2005–14: 13.9%; P = 0.04]. At logistic regression analysis, age at diagnosis >40 years (CD: odds ratio 1.73, 95% confidence interval [CI] 1.31–2.28, P < 0.0001; UC: 1.41, 95% CI 1.02–1.96, P = 0.04) and complicated disease at CD diagnosis [1.39, 95% CI 1.06–1.82, P = 0.02] were independently associated with a DD>24 months. Conclusions: DD duration has not changed over the last 60 years in Italy, but the number of IBD patients with a longer DD significantly decreased. Older age at diagnosis and a complicated disease at CD diagnosis are risk factors for longer DD.
KW - Age at diagnosis
KW - Crohn's disease
KW - Disease behaviour
KW - Misdiagnosis
KW - Ulcerative colitis
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U2 - 10.1093/ecco-jcc/jjx041
DO - 10.1093/ecco-jcc/jjx041
M3 - Article
AN - SCOPUS:85026655459
VL - 11
SP - 975
EP - 980
JO - Journal of Crohn's and Colitis
JF - Journal of Crohn's and Colitis
SN - 1873-9946
IS - 8
ER -