The Topical Administration of Bisphosphonates in Implant Surgery: A Randomized Split-Mouth Prospective Study with a Follow-Up Up to 5 Years

Francesco Zuffetti, Tiziano Testori, Matteo Capelli, Maria Cristina Rossi, Massimo Del Fabbro

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the efficacy of the topical administration of bisphosphonates in implant therapy. Materials and Methods: Thirty-nine consecutive patients were selected for a split-mouth study. Inclusion criteria were: presence of a bilateral or total edentulism, ability to tolerate conventional implant procedures, older than 18 years. Ten patients were smokers. Ten patients were fully edentulous in both maxilla and mandible, 12 patients had fully edentulous maxilla or mandible, and 17 were bilaterally partially edentulous (9 in the mandible and 8 in the maxilla). A one-stage procedure was adopted in all cases. The prosthetic phase started 10 weeks after implant insertion. Each patient received implants on the control side and the test side, with insertion performed in the conventional way on the control side; on the test side, a 3% clodronate solution mixed with a surfactant (Tween-20) at a 1:3 ratio was topically administered both at the implant surface and at the implant site. Results: One hundred fifty-five implants were inserted. The test and control groups included 75 and 80 implants, respectively. The implant insertion torque was no less than 30Ncm. A total of 7 implants failed in the control group (6 before loading and one after 12 months of loading). No failure occurred on the test side. By the 5-year follow-up, no further implant failure had been recorded. Overall, implant survival rates at 5 years for the test and control groups were, respectively, 100% and 91.3%, the difference being significant (p

Original languageEnglish
JournalClinical Implant Dentistry and Related Research
DOIs
Publication statusAccepted/In press - 2013

Keywords

  • Bisphosphonates
  • Dental implants
  • Edentulism

ASJC Scopus subject areas

  • Oral Surgery
  • Dentistry(all)

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