The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity: Comparison with the National Cancer Institute-Common Toxicity Scale

Guido Cavaletti, Barbara Frigeni, Francesca Lanzani, Marialuisa Piatti, Stefania Rota, Chiara Briani, Gabriella Zara, Rosaria Plasmati, Francesca Pastorelli, Augusto Caraceni, Andrea Pace, Mariagrazia Manicone, Andrea Lissoni, Nicoletta Colombo, Giulia Bianchi, Claudio Zanna

Research output: Contribution to journalArticle

Abstract

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major side effect of several antineoplastic drugs. However, despite its clinical importance, there is no agreement as to the best way to assess the severity and changes in CIPN. We have previously demonstrated a correlation between the severity of CIPN, assessed using the Total Neuropathy Score (TNS) or its reduced versions, and several common toxicity scales. In this study, we investigated two series of patients (total number = 173) who were evaluated at baseline and during chemotherapy with the TNS (n = 122) or the TNSc (the TNS version based exclusively on the clinical evaluation of the patients, n = 51) and with the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) 2.0, with the aim of comparing the sensitivity to the changes in CIPN severity. In both series, the TNS and the TNSc had a significant correlation with the NCI-CTC in scoring the severity of CIPN, confirming the results of previous studies. Moreover, both the TNS and the TNSc showed a higher sensitivity to CIPN changes. We, therefore, propose the TNSc as a reliable method for assessing not only the severity but also the changes in CIPN.

Original languageEnglish
Pages (from-to)210-215
Number of pages6
JournalJournal of the Peripheral Nervous System
Volume12
Issue number3
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Chemotherapy-induced peripheral neuropathy
  • Total Neuropathy Score

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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