TY - JOUR
T1 - The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy-induced peripheral neurotoxicity
T2 - Comparison with the National Cancer Institute-Common Toxicity Scale
AU - Cavaletti, Guido
AU - Frigeni, Barbara
AU - Lanzani, Francesca
AU - Piatti, Marialuisa
AU - Rota, Stefania
AU - Briani, Chiara
AU - Zara, Gabriella
AU - Plasmati, Rosaria
AU - Pastorelli, Francesca
AU - Caraceni, Augusto
AU - Pace, Andrea
AU - Manicone, Mariagrazia
AU - Lissoni, Andrea
AU - Colombo, Nicoletta
AU - Bianchi, Giulia
AU - Zanna, Claudio
PY - 2007/9
Y1 - 2007/9
N2 - Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major side effect of several antineoplastic drugs. However, despite its clinical importance, there is no agreement as to the best way to assess the severity and changes in CIPN. We have previously demonstrated a correlation between the severity of CIPN, assessed using the Total Neuropathy Score (TNS) or its reduced versions, and several common toxicity scales. In this study, we investigated two series of patients (total number = 173) who were evaluated at baseline and during chemotherapy with the TNS (n = 122) or the TNSc (the TNS version based exclusively on the clinical evaluation of the patients, n = 51) and with the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) 2.0, with the aim of comparing the sensitivity to the changes in CIPN severity. In both series, the TNS and the TNSc had a significant correlation with the NCI-CTC in scoring the severity of CIPN, confirming the results of previous studies. Moreover, both the TNS and the TNSc showed a higher sensitivity to CIPN changes. We, therefore, propose the TNSc as a reliable method for assessing not only the severity but also the changes in CIPN.
AB - Chemotherapy-induced peripheral neurotoxicity (CIPN) is a major side effect of several antineoplastic drugs. However, despite its clinical importance, there is no agreement as to the best way to assess the severity and changes in CIPN. We have previously demonstrated a correlation between the severity of CIPN, assessed using the Total Neuropathy Score (TNS) or its reduced versions, and several common toxicity scales. In this study, we investigated two series of patients (total number = 173) who were evaluated at baseline and during chemotherapy with the TNS (n = 122) or the TNSc (the TNS version based exclusively on the clinical evaluation of the patients, n = 51) and with the National Cancer Institute-Common Toxicity Criteria (NCI-CTC) 2.0, with the aim of comparing the sensitivity to the changes in CIPN severity. In both series, the TNS and the TNSc had a significant correlation with the NCI-CTC in scoring the severity of CIPN, confirming the results of previous studies. Moreover, both the TNS and the TNSc showed a higher sensitivity to CIPN changes. We, therefore, propose the TNSc as a reliable method for assessing not only the severity but also the changes in CIPN.
KW - Chemotherapy-induced peripheral neuropathy
KW - Total Neuropathy Score
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U2 - 10.1111/j.1529-8027.2007.00141.x
DO - 10.1111/j.1529-8027.2007.00141.x
M3 - Article
C2 - 17868248
AN - SCOPUS:34548637553
VL - 12
SP - 210
EP - 215
JO - Journal of the Peripheral Nervous System
JF - Journal of the Peripheral Nervous System
SN - 1085-9489
IS - 3
ER -