Tossicologia e prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. I. Linee guida per la prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. Società Italiana Valori di Riferimento e Cattedra di Medicina del Lavoro, Università di Brescia.

Translated title of the contribution: The toxicology and prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. I. Guide lines for the prevention of the risks of occupational exposure to aromatic polycyclic hydrocarbons. Società Italiana Valori di Riferimento and Cattedra di Medicina del Lavoro, Università di Brescia

L. Alessio, P. Apostoli, S. Porru, E. Clonfero, C. Minoia, G. Assennato, E. Bergamaschi, P. Carta, F. Cassano, M. Dell'Omo, M. L. Fiorentino, V. Foà, A. Forni, G. Gabbani, A. Izzotti, G. Mastrangelo, S. Pavanello, P. Sartorelli, F. Valerio

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

These guidelines mainly deal with prevention of carcinogenic effects following occupational exposure to polycyclic aromatic hydrocarbons (PAH). After some toxicological remarks, the guidelines define a possible method to demonstrate and evaluate occupational exposure to PAH. In particular, it is illustrated the strategy of environmental monitoring and indicated which PAH should be measured, with suggestion about the most appropriate analytical techniques. As regards biological monitoring, the 1-OH-pyreneseems to be currently the most useful indicator since it reflects the recent and global exposure to PAH. The guidelines also give elements to interpret monitoring data, taking into account environmental and biological reference and limit values suggested by some authors, Associations, or current regulations. The most important health effects are carcinogenic and excess risks have been described mainly for lung, bladder and skin cancer in some PAH exposed workers. The studies on cytogenetic effects showed contradictory results. On the basis of such information and current regulations, the guidelines show how to perform health surveillance in preventive and periodical examinations and how to proceed for the information and formation of exposed workers. It is not advisable, on the basis of the current scientific data, to screen asymptomatic PAH exposed workers for early diagnosis of lung or bladder cancer, nor it is opportune the use of tumor markers for health surveillance nor is genetic screening applicable for individual susceptibility evaluation outside research programs.

Original languageItalian
Pages (from-to)131-136
Number of pages6
JournalGiornale Italiano di Medicina del Lavoro ed Ergonomia
Volume19
Issue number4
Publication statusPublished - 1997

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Polycyclic Aromatic Hydrocarbons
Occupational Exposure
Toxicology
Guidelines
Environmental Monitoring
Urinary Bladder Neoplasms
Lung Neoplasms
Health
Genetic Testing
Skin Neoplasms
Tumor Biomarkers
Early Detection of Cancer
Cytogenetics
Reference Values

Cite this

Tossicologia e prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. I. Linee guida per la prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. Società Italiana Valori di Riferimento e Cattedra di Medicina del Lavoro, Università di Brescia. / Alessio, L.; Apostoli, P.; Porru, S.; Clonfero, E.; Minoia, C.; Assennato, G.; Bergamaschi, E.; Carta, P.; Cassano, F.; Dell'Omo, M.; Fiorentino, M. L.; Foà, V.; Forni, A.; Gabbani, G.; Izzotti, A.; Mastrangelo, G.; Pavanello, S.; Sartorelli, P.; Valerio, F.

In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 19, No. 4, 1997, p. 131-136.

Research output: Contribution to journalArticle

Alessio, L. ; Apostoli, P. ; Porru, S. ; Clonfero, E. ; Minoia, C. ; Assennato, G. ; Bergamaschi, E. ; Carta, P. ; Cassano, F. ; Dell'Omo, M. ; Fiorentino, M. L. ; Foà, V. ; Forni, A. ; Gabbani, G. ; Izzotti, A. ; Mastrangelo, G. ; Pavanello, S. ; Sartorelli, P. ; Valerio, F. / Tossicologia e prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. I. Linee guida per la prevenzione dei rischi da esposizione professionale a idrocarburi policiclici aromatici. Società Italiana Valori di Riferimento e Cattedra di Medicina del Lavoro, Università di Brescia. In: Giornale Italiano di Medicina del Lavoro ed Ergonomia. 1997 ; Vol. 19, No. 4. pp. 131-136.
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