The treatment of hyperinsulinemic hypoglycaemia in adults: an update

Maria Vittoria Davi, A. Pia, Valentina Guarnotta, G. Pizza, A. Colao, A. Faggiano, behalf of NIKE Group On behalf of NIKE Group, Manuela Albertelli, Emanuela Arvat, Roberto Baldelli, Alfredo Berruti, Antonio Bianchi, Lisa Bodei, Francesco Corcione, Gianfranco Delle Fave, Laura De Marinis, Gaetano De Rosa, Antonella Di Sarno, Alessandra Dicitore, Nicola FazioGiuseppe Fanciulli, Piero Ferolla, Diego Ferone, Angelina Filice, Marco Gallo, Carla Giordano, Dario Giuffrida, Andrea Lania, Francesco Logoluso, Paola Loli, Pasqualino Malandrino, Marco Manzoni, Massimo Marchetti, Chiara Martini, Erika Messina, Roberta Modica, Cecilia Motta, Mauro Papotti, Stefano Partelli, Giovanni Persico, Alessandro Piovesan, Alfredo Pontecorvi, Valeria Ramundo, Paola Razzore, Francesca Rota, Francesco Scavuzzo, Concetta Sciammarella, Giovanni Vitale, Maria Chiara Zatelli

Research output: Contribution to journalReview articlepeer-review


Background: Treatment of hyperinsulinemic hypoglycaemia (HH) is challenging due to the rarity of this condition and the difficulty of differential diagnosis. The aim of this article is to give an overview of the recent literature on the management of adult HH. Methods: A search for reviews, original articles, original case reports between 1995 and 2016 in PubMed using the following keywords: hyperinsulinemic hypoglycaemia, insulinoma, nesidioblastosis, gastric bypass, autoimmune hypoglycaemia, hyperinsulinism, treatment was performed. Results: One hundred and forty articles were selected and analysed focusing on the most recent treatments of HH. Conclusions: New approaches to treatment of HH are available including mini-invasive surgical techniques and alternative local–regional ablative therapy for benign insulinoma and everolimus for malignant insulinoma. A correct differential diagnosis is of paramount importance to avoid unnecessary surgical operations and to implement the appropriate treatment mainly in the uncommon forms of HH, such as nesidioblastosis and autoimmune hypoglycaemia.

Original languageEnglish
Pages (from-to)9-20
Number of pages12
JournalJournal of Endocrinological Investigation
Issue number1
Publication statusPublished - Jan 1 2017


  • Autoimmune hypoglycaemia
  • Hyperinsulinemic hypoglycaemia
  • Insulinoma
  • Nesidioblastosis
  • Treatment

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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