The treatment of low-grade septic non-unions

F. Verdoni, R. D. D'Amato, L. Mangiavini, M. D. Lombardo, G. M. Peretti

Research output: Contribution to journalArticlepeer-review


Non-union (or pseudoarthrosis) is defined as a fracture that fails to consolidate after 6 months from the trauma. Current conservative treatments consist of biological (i.e. with calcium, Vitamin D) and mechanical stimulation. Moreover, surgical approaches include the use of endomidollar nail osteosynthesis, compression plates that are often associated with bone grafts. External fixation is a valid surgical alternative especially in case of septic non-unions. Indeed, compression-distraction osteosynthesis results in a significant improvement in bone vascularisation and exerts a powerful osteoinductive stimulus on the non-union site. In this review, we will describe a cohort of patients affected by low-grade septic non-unions and treated with external fixation.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number4
Publication statusPublished - Sep 1 2017


  • External fixation
  • Infection
  • Non-union

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Physiology
  • Immunology
  • Oncology
  • Endocrinology
  • Physiology (medical)
  • Cancer Research


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