The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

A. Goldhirsch; R. Greiner; E. Dreher; G. Locher; B. W. Davis; J. P. Reinhard; R. Joss; K. W. Brunner

doi:10.1159/000215691

The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

A. Goldhirsch, R. Greiner, E. Dreher, G. Locher, B. W. Davis, J. P. Reinhard, R. Joss, K. W. Brunner

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Seventy-six evaluable patients with ovarian carcinoma stages FIGO IIb, IIe, III, and IV, either received cis-platin (P) (80mg/m² iv. day 1), melphalan (PAM) (12mg/m² i.v. day 2) and hexamethylmelamine (IIEXAPAMP) (135mg/m² orally days 8 to 21) or the same dose of cis-platin and melphalan but no hexamethylmelamine (PAMP) every four weeks. In 24 patients (32%) a surgically ascertained CR was achieved. 16 of these received follow-up radiation treatment to the whole abdomen. At present 19 patients are without relapse (average time 24 months). The trial has not been concluded. Particularly no predictions can be made on the value of follow-up radiation therapy in obtaining long-term remission rates.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Oncology Research and Treatment
Volume	8
Issue number	6
DOIs	https://doi.org/10.1159/000215691
Publication status	Published - 1985

Keywords

Chemotherapy
Ovarian cancer
RadiationReferences

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1159/000215691

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Goldhirsch, A., Greiner, R., Dreher, E., Locher, G., Davis, B. W., Reinhard, J. P., Joss, R., & Brunner, K. W. (1985). The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation. Oncology Research and Treatment, 8(6), 383-387. https://doi.org/10.1159/000215691

The treatment of ovarian cancer by a multimodality approach : Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation. / Goldhirsch, A.; Greiner, R.; Dreher, E.; Locher, G.; Davis, B. W.; Reinhard, J. P.; Joss, R.; Brunner, K. W.

In: Oncology Research and Treatment, Vol. 8, No. 6, 1985, p. 383-387.

Research output: Contribution to journal › Article › peer-review

Goldhirsch, A, Greiner, R, Dreher, E, Locher, G, Davis, BW, Reinhard, JP, Joss, R & Brunner, KW 1985, 'The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation', Oncology Research and Treatment, vol. 8, no. 6, pp. 383-387. https://doi.org/10.1159/000215691

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abstract = "Seventy-six evaluable patients with ovarian carcinoma stages FIGO IIb, IIe, III, and IV, either received cis-platin (P) (80mg/m2 iv. day 1), melphalan (PAM) (12mg/m2 i.v. day 2) and hexamethylmelamine (IIEXAPAMP) (135mg/m2 orally days 8 to 21) or the same dose of cis-platin and melphalan but no hexamethylmelamine (PAMP) every four weeks. In 24 patients (32%) a surgically ascertained CR was achieved. 16 of these received follow-up radiation treatment to the whole abdomen. At present 19 patients are without relapse (average time 24 months). The trial has not been concluded. Particularly no predictions can be made on the value of follow-up radiation therapy in obtaining long-term remission rates.",

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The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

Abstract

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ASJC Scopus subject areas

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