The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

A. Goldhirsch; R. Greiner; E. Dreher; G. Locher; B. W. Davis; J. P. Reinhard; R. Joss; K. W. Brunner

doi:10.1159/000215691

The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

A. Goldhirsch, R. Greiner, E. Dreher, G. Locher, B. W. Davis, J. P. Reinhard, R. Joss, K. W. Brunner

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

Seventy-six evaluable patients with ovarian carcinoma stages FIGO IIb, IIe, III, and IV, either received cis-platin (P) (80mg/m² iv. day 1), melphalan (PAM) (12mg/m² i.v. day 2) and hexamethylmelamine (IIEXAPAMP) (135mg/m² orally days 8 to 21) or the same dose of cis-platin and melphalan but no hexamethylmelamine (PAMP) every four weeks. In 24 patients (32%) a surgically ascertained CR was achieved. 16 of these received follow-up radiation treatment to the whole abdomen. At present 19 patients are without relapse (average time 24 months). The trial has not been concluded. Particularly no predictions can be made on the value of follow-up radiation therapy in obtaining long-term remission rates.

Original language	English
Pages (from-to)	383-387
Number of pages	5
Journal	Oncology Research and Treatment
Volume	8
Issue number	6
DOIs	https://doi.org/10.1159/000215691
Publication status	Published - 1985

Keywords

Chemotherapy
Ovarian cancer
RadiationReferences

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

Access to Document

10.1159/000215691

Cite this

Goldhirsch, A., Greiner, R., Dreher, E., Locher, G., Davis, B. W., Reinhard, J. P., Joss, R., & Brunner, K. W. (1985). The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation. Oncology Research and Treatment, 8(6), 383-387. https://doi.org/10.1159/000215691

Goldhirsch, A, Greiner, R, Dreher, E, Locher, G, Davis, BW, Reinhard, JP, Joss, R & Brunner, KW 1985, 'The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation', Oncology Research and Treatment, vol. 8, no. 6, pp. 383-387. https://doi.org/10.1159/000215691

@article{62897e4247e74cbb94b35aa60394b288,

title = "The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation",

abstract = "Seventy-six evaluable patients with ovarian carcinoma stages FIGO IIb, IIe, III, and IV, either received cis-platin (P) (80mg/m2 iv. day 1), melphalan (PAM) (12mg/m2 i.v. day 2) and hexamethylmelamine (IIEXAPAMP) (135mg/m2 orally days 8 to 21) or the same dose of cis-platin and melphalan but no hexamethylmelamine (PAMP) every four weeks. In 24 patients (32%) a surgically ascertained CR was achieved. 16 of these received follow-up radiation treatment to the whole abdomen. At present 19 patients are without relapse (average time 24 months). The trial has not been concluded. Particularly no predictions can be made on the value of follow-up radiation therapy in obtaining long-term remission rates.",

keywords = "Chemotherapy, Ovarian cancer, RadiationReferences",

author = "A. Goldhirsch and R. Greiner and E. Dreher and G. Locher and Davis, {B. W.} and Reinhard, {J. P.} and R. Joss and Brunner, {K. W.}",

year = "1985",

doi = "10.1159/000215691",

language = "English",

volume = "8",

pages = "383--387",

journal = "Oncology Research and Treatment",

issn = "2296-5270",

publisher = "S. Karger AG",

number = "6",

}

TY - JOUR

T1 - The treatment of ovarian cancer by a multimodality approach

T2 - Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

AU - Goldhirsch, A.

AU - Greiner, R.

AU - Dreher, E.

AU - Locher, G.

AU - Davis, B. W.

AU - Reinhard, J. P.

AU - Joss, R.

AU - Brunner, K. W.

PY - 1985

Y1 - 1985

N2 - Seventy-six evaluable patients with ovarian carcinoma stages FIGO IIb, IIe, III, and IV, either received cis-platin (P) (80mg/m2 iv. day 1), melphalan (PAM) (12mg/m2 i.v. day 2) and hexamethylmelamine (IIEXAPAMP) (135mg/m2 orally days 8 to 21) or the same dose of cis-platin and melphalan but no hexamethylmelamine (PAMP) every four weeks. In 24 patients (32%) a surgically ascertained CR was achieved. 16 of these received follow-up radiation treatment to the whole abdomen. At present 19 patients are without relapse (average time 24 months). The trial has not been concluded. Particularly no predictions can be made on the value of follow-up radiation therapy in obtaining long-term remission rates.

AB - Seventy-six evaluable patients with ovarian carcinoma stages FIGO IIb, IIe, III, and IV, either received cis-platin (P) (80mg/m2 iv. day 1), melphalan (PAM) (12mg/m2 i.v. day 2) and hexamethylmelamine (IIEXAPAMP) (135mg/m2 orally days 8 to 21) or the same dose of cis-platin and melphalan but no hexamethylmelamine (PAMP) every four weeks. In 24 patients (32%) a surgically ascertained CR was achieved. 16 of these received follow-up radiation treatment to the whole abdomen. At present 19 patients are without relapse (average time 24 months). The trial has not been concluded. Particularly no predictions can be made on the value of follow-up radiation therapy in obtaining long-term remission rates.

KW - Chemotherapy

KW - Ovarian cancer

KW - RadiationReferences

UR - http://www.scopus.com/inward/record.url?scp=0022403323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022403323&partnerID=8YFLogxK

U2 - 10.1159/000215691

DO - 10.1159/000215691

M3 - Article

C2 - 3937969

AN - SCOPUS:0022403323

VL - 8

SP - 383

EP - 387

JO - Oncology Research and Treatment

JF - Oncology Research and Treatment

SN - 2296-5270

IS - 6

ER -

The treatment of ovarian cancer by a multimodality approach: Remission induction with chemotherapy - hexa p amp and p amp regimens - followed by whole-abdominal radiation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this