TY - JOUR
T1 - The treatment of sleep disorders in Parkinson's disease
T2 - From research to clinical practice
AU - Loddo, Giuseppe
AU - Calandra-Buonaura, Giovanna
AU - Sambati, Luisa
AU - Giannini, Giulia
AU - Cecere, Annagrazia
AU - Cortelli, Pietro
AU - Provini, Federica
N1 - Ricercatore distaccato presso IRCCS a seguito Convenzione esclusiva con Università di Bologna (Calandra-Buonaura Giovanna, Cortelli Pietro, Provini Federica)
PY - 2017/2/16
Y1 - 2017/2/16
N2 - Sleep disorders (SDs) are one of the most frequent non-motor symptoms of Parkinson's disease (PD), usually increasing in frequency over the course of the disease and disability progression. SDs include nocturnal and diurnal manifestations such as insomnia, REM sleep behavior disorder, and excessive daytime sleepiness. The causes of SDs in PD are numerous, including the neurodegeneration process itself, which can disrupt the networks regulating the sleep-wake cycle and deplete a large number of cerebral amines possibly playing a role in the initiation and maintenance of sleep. Despite the significant prevalence of SDs in PD patients, few clinical trials on SDs treatment have been conducted. Our aim is to critically review the principal therapeutic options for the most common SDs in PD. The appropriate diagnosis and treatment of SDs in PD can lead to the consolidation of nocturnal sleep, the enhancement of daytime alertness, and the amelioration of the quality of life of the patients.
AB - Sleep disorders (SDs) are one of the most frequent non-motor symptoms of Parkinson's disease (PD), usually increasing in frequency over the course of the disease and disability progression. SDs include nocturnal and diurnal manifestations such as insomnia, REM sleep behavior disorder, and excessive daytime sleepiness. The causes of SDs in PD are numerous, including the neurodegeneration process itself, which can disrupt the networks regulating the sleep-wake cycle and deplete a large number of cerebral amines possibly playing a role in the initiation and maintenance of sleep. Despite the significant prevalence of SDs in PD patients, few clinical trials on SDs treatment have been conducted. Our aim is to critically review the principal therapeutic options for the most common SDs in PD. The appropriate diagnosis and treatment of SDs in PD can lead to the consolidation of nocturnal sleep, the enhancement of daytime alertness, and the amelioration of the quality of life of the patients.
KW - Excessive daytime sleepiness
KW - Insomnia
KW - Nocturia
KW - Parasomnias
KW - Sleep-related movement disorders
UR - http://www.scopus.com/inward/record.url?scp=85014244317&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014244317&partnerID=8YFLogxK
U2 - 10.3389/fneur.2017.00042
DO - 10.3389/fneur.2017.00042
M3 - Review article
C2 - 28261151
AN - SCOPUS:85014244317
VL - 8
JO - Frontiers in Neurology
JF - Frontiers in Neurology
SN - 1664-2295
IS - FEB
M1 - 42
ER -