IL TRATTAMENTO DELLA RISPOSTA IPERCINETICA ALLO SFORZO DOPO INFARTO MIOCARDICO. RISULTATI DI UNO STUDIO ERGOMETRICO RANDOMIZZATO

Translated title of the contribution: The treatment of the hyperkinetic response to exercise after myocardial infarction. Results of a randomized ergometric study

C. Opasich, R. Griffo, F. Cobelli, J. Assandri, R. Tramarin, M. T. Larovere, C. Vecchio

Research output: Contribution to journalArticle

Abstract

40 patients, showing a hyperkinetic response during an ergometric test 30 days after a myocardial infarction, were randomly divided into 4 groups consisting of 10 subjects and treated as follows. Group M: metoprolol 200 mg/die; Group P: propranolol 160 mg/die; Group A: amiodarone 400 mg/die; Group V: verapamil 240 mg/die. A new ergometric test was performed 15 days later. In every case the total work performed was higher in the second test than in the first one. Lowering of the maximal double product faced increasing of the total work performed. Submaximal HR, sBP and double product was found to be reduced after all the 4 treatments. These data confirm that pharmacological treatment is useful to readjust the cardiac work to the total external work. Two patients belonging to Groups M and P stopped the second test due to signs of pump failure. The author's conclusions are: the drugs tested here are useful to reduce the hyperkinetic response to exercise after myocardial infarction. Nevertheless, metoprolol and propranolol hold the risk of effort cardiac failure. On the contrary, verapamil and amiodarone do not seem to present this risk.

Original languageItalian
Pages (from-to)395-403
Number of pages9
JournalMinerva Cardioangiologica
Volume30
Issue number7-8
Publication statusPublished - 1982

Fingerprint

Myocardial Infarction
Exercise
Metoprolol
Amiodarone
Verapamil
Propranolol
Therapeutics
Heart Failure
Pharmacology
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

IL TRATTAMENTO DELLA RISPOSTA IPERCINETICA ALLO SFORZO DOPO INFARTO MIOCARDICO. RISULTATI DI UNO STUDIO ERGOMETRICO RANDOMIZZATO. / Opasich, C.; Griffo, R.; Cobelli, F.; Assandri, J.; Tramarin, R.; Larovere, M. T.; Vecchio, C.

In: Minerva Cardioangiologica, Vol. 30, No. 7-8, 1982, p. 395-403.

Research output: Contribution to journalArticle

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