The Tregs' world according to GARP

Manuela Battaglia, Maria Grazia Roncarolo

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Naturally occurring CD4+CD25high regulatory T cells (nTreg) are essential for maintaining tolerance. FOXP3 has been established as a molecular marker of nTreg; however, FOXP3 cannot be used as a reliable marker for bona fide human nTreg since effector T cells also up-regulate FOXP3 expression upon activation. Despite the important function of nTreg, the underlying molecular mechanisms of nTreg-mediated suppression are far from defined. Previous studies have demonstrated that the TGF-β latency-associated peptide (LAP) is expressed on the surface of nTreg, and that immunosuppression can be mediated by membrane TGF-β; however, it remains unknown how LAP is bound to nTreg and what is the functional significance of its selective expression on activated nTreg. The nTreg's world may now change according to GARP, an orphan toll-like receptor composed of leucine-rich repeats. In this issue of the European Journal of Immunology, a study provides further demonstration that GARP is selectively expressed only in activated human nTreg and nTreg cell clones but not in activated effector T cells, confirming GARP as a bona fide nTreg marker. In addition, GARP binds directly to LAP; yet, GARP over-expression is insufficient to induce modification of latent TGF-β into active TGF- further clarifying its role in nTreg-mediated suppression.

Original languageEnglish
Pages (from-to)3296-3300
Number of pages5
JournalEuropean Journal of Immunology
Volume39
Issue number12
DOIs
Publication statusPublished - Dec 2009

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Peptides
T-Lymphocytes
Orphaned Children
Toll-Like Receptors
Regulatory T-Lymphocytes
Allergy and Immunology
Leucine
Immunosuppression
Up-Regulation
Clone Cells
Membranes

Keywords

  • Regulatory T cells
  • T cells
  • Tolerance

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The Tregs' world according to GARP. / Battaglia, Manuela; Roncarolo, Maria Grazia.

In: European Journal of Immunology, Vol. 39, No. 12, 12.2009, p. 3296-3300.

Research output: Contribution to journalArticle

Battaglia, Manuela ; Roncarolo, Maria Grazia. / The Tregs' world according to GARP. In: European Journal of Immunology. 2009 ; Vol. 39, No. 12. pp. 3296-3300.
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