The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes

Sabrina Prudente, Daniela Scarpelli, Manisha Chandalia, Yuan Yuan Zhang, Eleonora Morini, Silvia Del Guerra, Francesco Perticone, Rong Li, Christine Powers, Francesco Andreozzi, Piero Marchetti, Bruno Dallapiccola, Nicola Abate, Alessandro Doria, Giorgio Sesti, Vincenzo Trischitta

Research output: Contribution to journalArticle

Abstract

Context: The prevalence of type 2 diabetes (T2D), particularly among young adults, has been rising steadily during the past 2 decades. T2D, especially in its early-onset subtype, is under genetic control. TRIB3 inhibits insulin-stimulated Akt phosphorylation and subsequent insulin action. A TRIB3 gain-of-function polymorphism, Q84R (rs2295490), impairs insulin signaling. Objective: The objective of the study was to verify the association of TRIB3 Q84R with: 1) T2D, either subtyped or not according to age at diagnosis (early-onset,

Original languageEnglish
Pages (from-to)190-196
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume94
Issue number1
DOIs
Publication statusPublished - Jan 2009

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ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Prudente, S., Scarpelli, D., Chandalia, M., Zhang, Y. Y., Morini, E., Del Guerra, S., Perticone, F., Li, R., Powers, C., Andreozzi, F., Marchetti, P., Dallapiccola, B., Abate, N., Doria, A., Sesti, G., & Trischitta, V. (2009). The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 94(1), 190-196. https://doi.org/10.1210/jc.2008-1365