The triggering receptor expressed on myeloid cells (TREM) in inflammatory bowel disease pathogenesis

Marco Genua, Sergio Rutella, Carmen Correale, Silvio Danese

Research output: Contribution to journalReview article

Abstract

The Triggering Receptors Expressed on Myeloid cells (TREM) are a family of cell-surface molecules that control inflammation, bone homeostasis, neurological development and blood coagulation. TREM-1 and TREM-2, the best-characterized receptors so far, play divergent roles in several infectious diseases. In the intestine, TREM-1 is highly expressed by macrophages, contributing to inflammatory bowel disease (IBD) pathogenesis. Contrary to current understanding, TREM-2 also promotes inflammation in IBD by fueling dendritic cell functions. This review will focus specifically on recent insights into the role of TREM proteins in IBD development, and discuss opportunities for novel treatment approaches.

Original languageEnglish
Article number293
JournalJournal of Translational Medicine
Volume12
Issue number1
DOIs
Publication statusPublished - 2014

Keywords

  • Bacterial sensing
  • Inflammation
  • Inflammatory bowel disease
  • Innate immunity
  • Myeloid cells
  • TREM

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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