The tripartite motif family identifies cell compartments

Alexandre Reymond, Germana Meroni, Anna Fantozzi, Giuseppe Merla, Stefano Cairo, Lucilla Luzi, Daniela Riganelli, Elena Zanaria, Silvia Messali, Silvia Cainarca, Alessandro Guffanti, Saverio Minucci, Pier Giuseppe Pelicci, Andrea Ballabio

Research output: Contribution to journalArticlepeer-review

Abstract

A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a triparite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.

Original languageEnglish
Pages (from-to)2140-2151
Number of pages12
JournalEMBO Journal
Volume20
Issue number9
DOIs
Publication statusPublished - May 1 2001

Keywords

  • Cell compartmentalization
  • Functional genomics
  • Nuclear bodies
  • RBCC
  • Tripartite motif

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

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