The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

GA Ramirez, LA Coletto, EP Bozzolo, L Citterio, S Delli Carpini, L Zagato, P Rovere-Querini, C Lanzani, P Manunta, AA Manfredi, C Sciorati

Research output: Contribution to journalArticle

Abstract

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents. © 2018 Elsevier B.V.
Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalJournal of Neuroimmunology
Volume325
DOIs
Publication statusPublished - 2018

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Transient Receptor Potential Channels
Nervous System Diseases
Genotype
Systemic Lupus Erythematosus
Calcium
Single Nucleotide Polymorphism
Blood Cells
Apoptosis
Cytokines
Genes

Cite this

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title = "The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function",
abstract = "Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents. {\circledC} 2018 Elsevier B.V.",
author = "GA Ramirez and LA Coletto and EP Bozzolo and L Citterio and {Delli Carpini}, S and L Zagato and P Rovere-Querini and C Lanzani and P Manunta and AA Manfredi and C Sciorati",
year = "2018",
doi = "10.1016/j.jneuroim.2018.10.010",
language = "English",
volume = "325",
pages = "43--53",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier Science B.V.",

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TY - JOUR

T1 - The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

AU - Ramirez, GA

AU - Coletto, LA

AU - Bozzolo, EP

AU - Citterio, L

AU - Delli Carpini, S

AU - Zagato, L

AU - Rovere-Querini, P

AU - Lanzani, C

AU - Manunta, P

AU - Manfredi, AA

AU - Sciorati, C

PY - 2018

Y1 - 2018

N2 - Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents. © 2018 Elsevier B.V.

AB - Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents. © 2018 Elsevier B.V.

U2 - 10.1016/j.jneuroim.2018.10.010

DO - 10.1016/j.jneuroim.2018.10.010

M3 - Article

VL - 325

SP - 43

EP - 53

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -