Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents. © 2018 Elsevier B.V.
Ramirez, GA., Coletto, LA., Bozzolo, EP., Citterio, L., Delli Carpini, S., Zagato, L., Rovere-Querini, P., Lanzani, C., Manunta, P., Manfredi, AA., & Sciorati, C. (2018). The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function. Journal of Neuroimmunology, 325, 43-53. https://doi.org/10.1016/j.jneuroim.2018.10.010