The TRPC6 intronic polymorphism, associated with the risk of neurological disorders in systemic lupus erythematous, influences immune cell function

GA Ramirez, LA Coletto, EP Bozzolo, L Citterio, S Delli Carpini, L Zagato, P Rovere-Querini, C Lanzani, P Manunta, AA Manfredi, C Sciorati

Research output: Contribution to journalArticle

Abstract

Patients with systemic lupus erythematosus (SLE) carrying a TT genotype for the rs7925662 single nucleotide polymorphism (SNP) in the transient receptor potential canonical channel 6 (TRPC6) gene are more likely to develop neuropsychiatric manifestations (NPSLE). We functionally characterised the effects of TRPC6 on peripheral blood mononuclear cells from 18 patients with SLE and 8 healthy controls with a known genotype. TRPC6 influenced calcium currents, apoptosis rates and cytokine secretion in a disease- and genotype-dependent manner. Cells from TT patients with NPSLE were more dependent on TRPC6 for the generation of calcium currents. © 2018 Elsevier B.V.
Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalJournal of Neuroimmunology
Volume325
DOIs
Publication statusPublished - 2018

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