The tuberous sclerosis complex: Balancing proliferation and survival

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Mutations in genes encoding either hamartin [TSC1 (tuberous sclerosis complex 1)] or tuberin (TSC2) result in a multisystem disorder characterized by the development of benign tumours and hamartomas in several organs. The TSC1 and TSC2 proteins form a complex that lies at the crossroad of many signalling pathways integrating the energy status of the cell with signals induced by nutrients and growth factors. The TSC1/2 complex is a critical negative regulator of mTORC1 [mTOR (mammalian target of rapamycin) complex 1], and by that controls anabolic processes to promote cell growth, proliferation and survival. In the present paper, we review recent evidence highlighting the notion that the TSC1/2 complex simultaneously controls mTOR-dependent andmTOR-independent signals critical for the balancing of cell proliferation and cell death.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Tuberous Sclerosis
Cell Proliferation
Gene encoding
Hamartoma
Cell proliferation
Cell growth
Cell death
Nutrients
Tumors
Cell Survival
Intercellular Signaling Peptides and Proteins
Cell Death
Food
Mutation
Growth
Genes
Neoplasms
Proteins
mechanistic target of rapamycin complex 1
Tuberous Sclerosis 1

Keywords

  • Cell growth
  • Mammalian target of rapamycin (mTOR)
  • Metabolism
  • Proliferation
  • Survival
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Biochemistry

Cite this

The tuberous sclerosis complex : Balancing proliferation and survival. / Tomasoni, Romana; Mondino, Anna.

In: Biochemical Society Transactions, Vol. 39, No. 2, 04.2011, p. 466-471.

Research output: Contribution to journalArticle

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