The tuberous sclerosis complex: Balancing proliferation and survival

Romana Tomasoni, Anna Mondino

Research output: Contribution to journalArticle

Abstract

Mutations in genes encoding either hamartin [TSC1 (tuberous sclerosis complex 1)] or tuberin (TSC2) result in a multisystem disorder characterized by the development of benign tumours and hamartomas in several organs. The TSC1 and TSC2 proteins form a complex that lies at the crossroad of many signalling pathways integrating the energy status of the cell with signals induced by nutrients and growth factors. The TSC1/2 complex is a critical negative regulator of mTORC1 [mTOR (mammalian target of rapamycin) complex 1], and by that controls anabolic processes to promote cell growth, proliferation and survival. In the present paper, we review recent evidence highlighting the notion that the TSC1/2 complex simultaneously controls mTOR-dependent andmTOR-independent signals critical for the balancing of cell proliferation and cell death.

Original languageEnglish
Pages (from-to)466-471
Number of pages6
JournalBiochemical Society Transactions
Volume39
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Cell growth
  • Mammalian target of rapamycin (mTOR)
  • Metabolism
  • Proliferation
  • Survival
  • Tuberous sclerosis

ASJC Scopus subject areas

  • Biochemistry

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