The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells

Angelo Cicalese, Giuseppina Bonizzi, Cristina E. Pasi, Mario Faretta, Simona Ronzoni, Barbara Giulini, Cathrin Brisken, Saverio Minucci, Pier Paolo Di Fiore, Pier Giuseppe Pelicci

Research output: Contribution to journalArticlepeer-review


Stem-like cells may be integral to the development and maintenance of human cancers. Direct proof is still lacking, mainly because of our poor understanding of the biological differences between normal and cancer stem cells (SCs). Using the ErbB2 transgenic model of breast cancer, we found that self-renewing divisions of cancer SCs are more frequent than their normal counterparts, unlimited and symmetric, thus contributing to increasing numbers of SCs in tumoral tissues. SCs with targeted mutation of the tumor suppressor p53 possess the same self-renewal properties as cancer SCs, and their number increases progressively in the p53 null premalignant mammary gland. Pharmacological reactivation of p53 correlates with restoration of asymmetric divisions in cancer SCs and tumor growth reduction, without significant effects on additional cancer cells. These data demonstrate that p53 regulates polarity of cell division in mammary SCs and suggest that loss of p53 favors symmetric divisions of cancer SCs, contributing to tumor growth.

Original languageEnglish
Pages (from-to)1083-1095
Number of pages13
Issue number6
Publication statusPublished - Sep 18 2009



ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells'. Together they form a unique fingerprint.

Cite this