The type II 'decoy' receptor: A novel regulatory pathway for interleukin 1

Francesco Colotta, Steven K. Dower, John E. Sims, Alberto Mantovani

Research output: Contribution to journalArticlepeer-review

Abstract

The interleukin 1 (IL-1) system plays a central role in inflammation and immunity. Of the two receptors that bind IL-1, the type I receptor is known to mediate signaling activity, whereas the function of the type II receptor remains unknown. Here, Francesco Colotta and colleagues review the properties of these receptors and summarize evidence indicating that the type II receptor acts as a regulated decoy target for IL-1.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
JournalTrends in Immunology
Volume15
Issue number12
Publication statusPublished - Dec 1994

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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