The type II 'decoy' receptor: A novel regulatory pathway for interleukin 1

Francesco Colotta, Steven K. Dower, John E. Sims, Alberto Mantovani

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The interleukin 1 (IL-1) system plays a central role in inflammation and immunity. Of the two receptors that bind IL-1, the type I receptor is known to mediate signaling activity, whereas the function of the type II receptor remains unknown. Here, Francesco Colotta and colleagues review the properties of these receptors and summarize evidence indicating that the type II receptor acts as a regulated decoy target for IL-1.

Original languageEnglish
Pages (from-to)562-566
Number of pages5
JournalTrends in Immunology
Volume15
Issue number12
Publication statusPublished - Dec 1994

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Interleukin-1
Interleukin-1 Type I Receptors
Immunity
Inflammation

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

The type II 'decoy' receptor : A novel regulatory pathway for interleukin 1. / Colotta, Francesco; Dower, Steven K.; Sims, John E.; Mantovani, Alberto.

In: Trends in Immunology, Vol. 15, No. 12, 12.1994, p. 562-566.

Research output: Contribution to journalArticle

Colotta, F, Dower, SK, Sims, JE & Mantovani, A 1994, 'The type II 'decoy' receptor: A novel regulatory pathway for interleukin 1', Trends in Immunology, vol. 15, no. 12, pp. 562-566.
Colotta, Francesco ; Dower, Steven K. ; Sims, John E. ; Mantovani, Alberto. / The type II 'decoy' receptor : A novel regulatory pathway for interleukin 1. In: Trends in Immunology. 1994 ; Vol. 15, No. 12. pp. 562-566.
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