The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody

F. Piovella; G. Nalli; G. D. Malamani; I. Majolino; F. Frassoni; G. M. Sitar; A. Ruggeri; C. Dell'Orbo; E. Ascari

The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody

F. Piovella, G. Nalli, G. D. Malamani, I. Majolino, F. Frassoni, G. M. Sitar, A. Ruggeri, C. Dell'Orbo, E. Ascari

Research output: Contribution to journal › Article › peer-review

Abstract

By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.

Original language	English
Pages (from-to)	209-213
Number of pages	5
Journal	British Journal of Haematology
Volume	39
Issue number	2
Publication status	Published - 1978

ASJC Scopus subject areas

Hematology

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The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. / Piovella, F.; Nalli, G.; Malamani, G. D.; Majolino, I.; Frassoni, F.; Sitar, G. M.; Ruggeri, A.; Dell'Orbo, C.; Ascari, E.

In: British Journal of Haematology, Vol. 39, No. 2, 1978, p. 209-213.

Research output: Contribution to journal › Article › peer-review

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abstract = "By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.",

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AU - Majolino, I.

AU - Frassoni, F.

AU - Sitar, G. M.

AU - Ruggeri, A.

AU - Dell'Orbo, C.

AU - Ascari, E.

PY - 1978

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