The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody

F. Piovella, G. Nalli, G. D. Malamani, I. Majolino, F. Frassoni, G. M. Sitar, A. Ruggeri, C. Dell'Orbo, E. Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalBritish Journal of Haematology
Volume39
Issue number2
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Hematology

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