The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody

F. Piovella, G. Nalli, G. D. Malamani, I. Majolino, F. Frassoni, G. M. Sitar, A. Ruggeri, C. Dell'Orbo, E. Ascari

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Abstract

By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalBritish Journal of Haematology
Volume39
Issue number2
Publication statusPublished - 1978

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ASJC Scopus subject areas

  • Hematology

Cite this

Piovella, F., Nalli, G., Malamani, G. D., Majolino, I., Frassoni, F., Sitar, G. M., Ruggeri, A., Dell'Orbo, C., & Ascari, E. (1978). The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. British Journal of Haematology, 39(2), 209-213.