Abstract
By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.
| Original language | English |
|---|---|
| Pages (from-to) | 209-213 |
| Number of pages | 5 |
| Journal | British Journal of Haematology |
| Volume | 39 |
| Issue number | 2 |
| Publication status | Published - 1978 |
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ASJC Scopus subject areas
- Hematology
Cite this
Piovella, F., Nalli, G., Malamani, G. D., Majolino, I., Frassoni, F., Sitar, G. M., Ruggeri, A., Dell'Orbo, C., & Ascari, E. (1978). The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. British Journal of Haematology, 39(2), 209-213.