Abstract
By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.
| Original language | English |
|---|---|
| Pages (from-to) | 209-213 |
| Number of pages | 5 |
| Journal | British Journal of Haematology |
| Volume | 39 |
| Issue number | 2 |
| Publication status | Published - 1978 |
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ASJC Scopus subject areas
- Hematology
Cite this
The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. / Piovella, F.; Nalli, G.; Malamani, G. D.; Majolino, I.; Frassoni, F.; Sitar, G. M.; Ruggeri, A.; Dell'Orbo, C.; Ascari, E.
In: British Journal of Haematology, Vol. 39, No. 2, 1978, p. 209-213.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody
AU - Piovella, F.
AU - Nalli, G.
AU - Malamani, G. D.
AU - Majolino, I.
AU - Frassoni, F.
AU - Sitar, G. M.
AU - Ruggeri, A.
AU - Dell'Orbo, C.
AU - Ascari, E.
PY - 1978
Y1 - 1978
N2 - By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.
AB - By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018140267&partnerID=8YFLogxK
M3 - Article
VL - 39
SP - 209
EP - 213
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 2
ER -