The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody

F. Piovella, G. Nalli, G. D. Malamani, I. Majolino, F. Frassoni, G. M. Sitar, A. Ruggeri, C. Dell'Orbo, E. Ascari

Research output: Contribution to journalArticle

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Abstract

By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.

Original languageEnglish
Pages (from-to)209-213
Number of pages5
JournalBritish Journal of Haematology
Volume39
Issue number2
Publication statusPublished - 1978

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Human Platelet Antigens
Factor VII
Megakaryocytes
Ferritins
Endothelial Cells
Antibodies
Blood Platelets
Factor VIII
Electron Microscopy
Antigens

ASJC Scopus subject areas

  • Hematology

Cite this

The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. / Piovella, F.; Nalli, G.; Malamani, G. D.; Majolino, I.; Frassoni, F.; Sitar, G. M.; Ruggeri, A.; Dell'Orbo, C.; Ascari, E.

In: British Journal of Haematology, Vol. 39, No. 2, 1978, p. 209-213.

Research output: Contribution to journalArticle

Piovella, F. ; Nalli, G. ; Malamani, G. D. ; Majolino, I. ; Frassoni, F. ; Sitar, G. M. ; Ruggeri, A. ; Dell'Orbo, C. ; Ascari, E. / The ultrastructural localization of factor VII-antigen in human platelets, megakaryocytes and endothelial cells utilizing a ferritin-labelled antibody. In: British Journal of Haematology. 1978 ; Vol. 39, No. 2. pp. 209-213.
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