Abstract
By means of electron microscopy combined with the use of monospecific anti-factor VIII-antigen (VIIIR:AG) antibodies conjugated to ferritin, the subcellular localization of VIIIR:AG in platelets, megakaryocytes and in endothelial cells has been established. The reported results suggest the possibility that the megakaryocyte is able to synthesize VIIIR:AG and also to secrete it by means of a microcanalicular system similar to that present in the endothelial cell. Platelets may derive their VIIIR:AG content partly from the megakaryocyte and partly from the plasma.
Original language | English |
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Pages (from-to) | 209-213 |
Number of pages | 5 |
Journal | British Journal of Haematology |
Volume | 39 |
Issue number | 2 |
Publication status | Published - 1978 |
ASJC Scopus subject areas
- Hematology