LE BASI MORFOGENETICHE ULTRASTRUTTURALI DELLA 'ADULT RESPIRATORY DISTRESS SYNDROME' (ARDS)

Translated title of the contribution: The ultrastructural morphogenetic bases of the adult respiratory distress syndrome

V. Di Carlo, C. Staudacher, R. Chiesa

Research output: Contribution to journalArticlepeer-review

Abstract

Sequential study of the submicroscipic pathological events characterising the natural history of adult respiratory distress syndrome has pinpointed three different development stages related to clinical course and prognosis. In the first stage, the decisive biological element is represented by the increase in capillary permeability, whose morphological substrate consists of the distension of intercell junctions. The result is the formation of interstitial oedema with the characteristics of the exudate. In the second stage, when reversibility is still possible, fluid and proteins pass into the alveolus. Finally, in the third stage, the persisting stimulus of pulmonary capillaries leads to the formation of hyaline membranes and to a reactive lung response in the form of interstitial fibrinogenesis and hyperplasia of granular pneumocytes.

Translated title of the contributionThe ultrastructural morphogenetic bases of the adult respiratory distress syndrome
Original languageItalian
Pages (from-to)979-999
Number of pages21
JournalMinerva Anestesiologica
Volume46
Issue number9
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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