In recent years, the transitional phase between normal aging and very early dementia, more specifically Alzheimer's disease (AD), has become a topic of great interest for research. The concept of Mild Cognitive Impairment (MCI) was introduced to define the transitional phase between normal aging and dementia. The criteria for diagnosing MCI identify a category of subjects with a significantly increased risk to develop AD. However, until now the variability in applying MCI criteria in research studies and the lack of sufficiently extended longitudinal studies have prevented a definitive estimate of the risk of developing AD in this category of subjects. On the other hand, other categories of subjects, such as those affected by sub-clinical deficits of other cognitive functions besides memory, may represent early forms of AD. Future research will be needed to clarify boundaries and criteria for the pre-clinical diagnosis of AD.
|Translated title of the contribution||The uncertain boundaries between aging and dementia|
|Number of pages||5|
|Journal||Giornale di Gerontologia|
|Publication status||Published - Oct 2003|
ASJC Scopus subject areas
- Geriatrics and Gerontology