TY - JOUR
T1 - The unleashing of the immune system in COVID-19 and sepsis
T2 - the calm before the storm?
AU - Bellinvia, Salvatore
AU - Edwards, Christopher J.
AU - Schisano, Matteo
AU - Banfi, Paolo
AU - Fallico, Matteo
AU - Murabito, Paolo
PY - 2020/5/1
Y1 - 2020/5/1
N2 - The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sorely testing health care systems and economies around the world and is rightly considered as the major health emergency in a century. Despite the course of the disease appearing to be mild in many cases, a significant proportion of symptomatic patients develop pneumonia requiring hospitalisation or progress to manifest respiratory complications leading to intensive care treatment. Potential interventions for SARS-CoV2-associated pneumonia are being tested, some of which holding promise, but as of today none of these has yet demonstrated outstanding efficacy in treating COVID-19. In this article, we discuss fresh perspectives and insights into the potential role of immune dysregulation in COVID-19 as well as similarities with systemic inflammatory response in sepsis and the rationale for exploring novel treatment options affecting host immune response.
AB - The novel coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is sorely testing health care systems and economies around the world and is rightly considered as the major health emergency in a century. Despite the course of the disease appearing to be mild in many cases, a significant proportion of symptomatic patients develop pneumonia requiring hospitalisation or progress to manifest respiratory complications leading to intensive care treatment. Potential interventions for SARS-CoV2-associated pneumonia are being tested, some of which holding promise, but as of today none of these has yet demonstrated outstanding efficacy in treating COVID-19. In this article, we discuss fresh perspectives and insights into the potential role of immune dysregulation in COVID-19 as well as similarities with systemic inflammatory response in sepsis and the rationale for exploring novel treatment options affecting host immune response.
KW - Checkpoint inhibitors
KW - Covid-19
KW - Cytokine storm
KW - Immune dysregulation
KW - Inflammatory receptors
KW - Sepsis
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U2 - 10.1007/s00011-020-01366-6
DO - 10.1007/s00011-020-01366-6
M3 - Article
AN - SCOPUS:85085506657
JO - Inflammation Research
JF - Inflammation Research
SN - 1023-3830
ER -