The unusual genetics of human longevity.

Giovanna De Benedictis, Claudio Franceschi

Research output: Contribution to journalArticlepeer-review

Abstract

In no species other than humans do cultural, social, and biological factors interact with each other in modulating complex phenotypes. Thus, the identification of genetic factors that affect human longevity is a true challenge. The model of centenarians provides us a unique opportunity to tackle this challenge. In this Perspective, we discuss some recent findings (the impact of geography and demography on the longevity phenotype, the relationship between longevity and homozygosity, the role of the nuclear-mitochondrial genome cross-talk) by which new ideas are suggested, such as the concept of a complex allele timing as a pivotal process in modulating the probability of achieving longevity.

Original languageEnglish
JournalScience of aging knowledge environment : SAGE KE
Volume2006
Issue number10
DOIs
Publication statusPublished - May 25 2006

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