TY - JOUR
T1 - The unusual genetics of human longevity.
AU - De Benedictis, Giovanna
AU - Franceschi, Claudio
PY - 2006/5/25
Y1 - 2006/5/25
N2 - In no species other than humans do cultural, social, and biological factors interact with each other in modulating complex phenotypes. Thus, the identification of genetic factors that affect human longevity is a true challenge. The model of centenarians provides us a unique opportunity to tackle this challenge. In this Perspective, we discuss some recent findings (the impact of geography and demography on the longevity phenotype, the relationship between longevity and homozygosity, the role of the nuclear-mitochondrial genome cross-talk) by which new ideas are suggested, such as the concept of a complex allele timing as a pivotal process in modulating the probability of achieving longevity.
AB - In no species other than humans do cultural, social, and biological factors interact with each other in modulating complex phenotypes. Thus, the identification of genetic factors that affect human longevity is a true challenge. The model of centenarians provides us a unique opportunity to tackle this challenge. In this Perspective, we discuss some recent findings (the impact of geography and demography on the longevity phenotype, the relationship between longevity and homozygosity, the role of the nuclear-mitochondrial genome cross-talk) by which new ideas are suggested, such as the concept of a complex allele timing as a pivotal process in modulating the probability of achieving longevity.
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U2 - 10.1126/sageke.2006.10.pe20
DO - 10.1126/sageke.2006.10.pe20
M3 - Article
C2 - 16807484
AN - SCOPUS:33746519271
VL - 2006
JO - Science of aging knowledge environment [electronic resource] : SAGE KE
JF - Science of aging knowledge environment [electronic resource] : SAGE KE
SN - 1539-6150
IS - 10
ER -