Abstract
The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis). The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating cell migration, adhesion and cytoskeletal status. However, recent evidence highlights an intricate relationship linking the uPA/uPAR system to cell growth and apoptosis.
| Original language | English |
|---|---|
| Pages (from-to) | 205-211 |
| Number of pages | 7 |
| Journal | Thrombosis and Haemostasis |
| Volume | 93 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2005 |
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Keywords
- Apoptosis
- Cell proliferation
- Tumour progression
- Urokinase
- Urokinase receptor
ASJC Scopus subject areas
- Hematology
Cite this
The urokinase plasminogen activator and its receptor. Role in cell growth and apoptosis. / Alfano, Daniela; Franco, Paola; Vocca, Immacolata; Gambi, Nadia; Pisa, Viviana; Mancini, Alessandro; Caputi, Mario; Carriero, Maria Vincenza; Iaccarino, Ingram; Stoppelli, Maria Patrizia.
In: Thrombosis and Haemostasis, Vol. 93, No. 2, 02.2005, p. 205-211.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The urokinase plasminogen activator and its receptor. Role in cell growth and apoptosis
AU - Alfano, Daniela
AU - Franco, Paola
AU - Vocca, Immacolata
AU - Gambi, Nadia
AU - Pisa, Viviana
AU - Mancini, Alessandro
AU - Caputi, Mario
AU - Carriero, Maria Vincenza
AU - Iaccarino, Ingram
AU - Stoppelli, Maria Patrizia
PY - 2005/2
Y1 - 2005/2
N2 - The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis). The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating cell migration, adhesion and cytoskeletal status. However, recent evidence highlights an intricate relationship linking the uPA/uPAR system to cell growth and apoptosis.
AB - The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis). The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating cell migration, adhesion and cytoskeletal status. However, recent evidence highlights an intricate relationship linking the uPA/uPAR system to cell growth and apoptosis.
KW - Apoptosis
KW - Cell proliferation
KW - Tumour progression
KW - Urokinase
KW - Urokinase receptor
UR - http://www.scopus.com/inward/record.url?scp=13844256438&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844256438&partnerID=8YFLogxK
U2 - 10.1160/TH04-09-0592
DO - 10.1160/TH04-09-0592
M3 - Article
VL - 93
SP - 205
EP - 211
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 2
ER -