The urokinase plasminogen activator and its receptor. Role in cell growth and apoptosis

Daniela Alfano, Paola Franco, Immacolata Vocca, Nadia Gambi, Viviana Pisa, Alessandro Mancini, Mario Caputi, Maria Vincenza Carriero, Ingram Iaccarino, Maria Patrizia Stoppelli

Research output: Contribution to journalArticlepeer-review

Abstract

The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis). The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. The urokinase receptor (uPAR), binding to the EGF-like domain of uPA, directs membrane-associated extracellular proteolysis and signals through transmembrane proteins, thus regulating cell migration, adhesion and cytoskeletal status. However, recent evidence highlights an intricate relationship linking the uPA/uPAR system to cell growth and apoptosis.

Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalThrombosis and Haemostasis
Volume93
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Apoptosis
  • Cell proliferation
  • Tumour progression
  • Urokinase
  • Urokinase receptor

ASJC Scopus subject areas

  • Hematology

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