The use of a numerical model to simulate the cavo-pulmonary assistance in Fontan circulation

a preliminary verification

Arianna Di Molfetta, Antonio Amodeo, Libera Fresiello, Sergio Filippelli, Mara Pilati, Roberta Iacobelli, Rachele Adorisio, Dionisio Colella, Gianfranco Ferrari

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The lack of an established experience on the use of VAD for the cavo-pulmonary assistance leads to the need of dedicated VADs development and animal experiments. A dedicated numerical model could support clinical and experimental strategies design and new VADs testing. The aim of this work is to perform a preliminary verification of a lumped parameter model of the cardiovascular system to simulate Fontan physiology and the effect of cavo-pulmonary assistance. Literature data of 4 pigs were used to simulate animals’ baseline, and then the model was tested in simulating Fontan circulation and cavo-pulmonary-assisted condition comparing the simulation outcome (Sim) with measured literature data (Me). The results show that the numerical model can well reproduce experimental data in all three conditions (baseline, Fontan and assisted Fontan) [cardiac output (l/min): Me = 2.8 ± 1.7, Sim = 2.8 ± 1.8; ejection fraction (%): Me = 57 ± 17, Sim = 54 ± 17; arterial systemic pressure (mmHg): Me = 41.8 ± 18.6, Sim = 43.8 ± 18.1; pulmonary arterial pressure (mmHg): Me = 15.4 ± 8.9, Sim = 17.7 ± 9.9; caval pressure (mmHg): Me = 6.8 ± 4.1, Sim = 7 ± 4.6]. Systolic elastance, arterial systemic and arterial pulmonary resistances increase (10, 69, and 100 %) passing from the biventricular circulation to the Fontan physiology and then decrease (21, 39, and 50 %) once the VAD was implanted. The ventricular external work decreases (71 %) passing from the biventricular circulation to the Fontan physiology and it increases three times after the VAD implantation in parallel with the VAD power consumption. A numerical model could support clinicians in an innovative and challenging field as the use of VAD to assist the Fontan physiology and it could be helpful to personalize the VAD insertion on the base of ventricular systo-diastolic function, circulatory parameters and energetic variables.

Original languageEnglish
JournalJournal of Artificial Organs
DOIs
Publication statusAccepted/In press - Nov 6 2015

Fingerprint

Physiology
Numerical models
Lung
Arterial Pressure
Animals
Cardiovascular system
Venae Cavae
Pulmonary Circulation
Cardiovascular System
Cardiac Output
Design of experiments
Electric power utilization
Research Design
Swine
Pressure
Testing
Experiments

Keywords

  • Fontan
  • Lumped parameter model
  • VAD

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine
  • Medicine (miscellaneous)

Cite this

The use of a numerical model to simulate the cavo-pulmonary assistance in Fontan circulation : a preliminary verification. / Di Molfetta, Arianna; Amodeo, Antonio; Fresiello, Libera; Filippelli, Sergio; Pilati, Mara; Iacobelli, Roberta; Adorisio, Rachele; Colella, Dionisio; Ferrari, Gianfranco.

In: Journal of Artificial Organs, 06.11.2015.

Research output: Contribution to journalArticle

Di Molfetta, Arianna ; Amodeo, Antonio ; Fresiello, Libera ; Filippelli, Sergio ; Pilati, Mara ; Iacobelli, Roberta ; Adorisio, Rachele ; Colella, Dionisio ; Ferrari, Gianfranco. / The use of a numerical model to simulate the cavo-pulmonary assistance in Fontan circulation : a preliminary verification. In: Journal of Artificial Organs. 2015.
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abstract = "The lack of an established experience on the use of VAD for the cavo-pulmonary assistance leads to the need of dedicated VADs development and animal experiments. A dedicated numerical model could support clinical and experimental strategies design and new VADs testing. The aim of this work is to perform a preliminary verification of a lumped parameter model of the cardiovascular system to simulate Fontan physiology and the effect of cavo-pulmonary assistance. Literature data of 4 pigs were used to simulate animals’ baseline, and then the model was tested in simulating Fontan circulation and cavo-pulmonary-assisted condition comparing the simulation outcome (Sim) with measured literature data (Me). The results show that the numerical model can well reproduce experimental data in all three conditions (baseline, Fontan and assisted Fontan) [cardiac output (l/min): Me = 2.8 ± 1.7, Sim = 2.8 ± 1.8; ejection fraction ({\%}): Me = 57 ± 17, Sim = 54 ± 17; arterial systemic pressure (mmHg): Me = 41.8 ± 18.6, Sim = 43.8 ± 18.1; pulmonary arterial pressure (mmHg): Me = 15.4 ± 8.9, Sim = 17.7 ± 9.9; caval pressure (mmHg): Me = 6.8 ± 4.1, Sim = 7 ± 4.6]. Systolic elastance, arterial systemic and arterial pulmonary resistances increase (10, 69, and 100 {\%}) passing from the biventricular circulation to the Fontan physiology and then decrease (21, 39, and 50 {\%}) once the VAD was implanted. The ventricular external work decreases (71 {\%}) passing from the biventricular circulation to the Fontan physiology and it increases three times after the VAD implantation in parallel with the VAD power consumption. A numerical model could support clinicians in an innovative and challenging field as the use of VAD to assist the Fontan physiology and it could be helpful to personalize the VAD insertion on the base of ventricular systo-diastolic function, circulatory parameters and energetic variables.",
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