The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma Mansoni infection in migrants in Italy, a non-endemic country: A cross sectional study

L Infurnari, L Galli, A Bigoloni, A Carbone, S Chiappetta, A Sala, N Ceserani, A Lazzarin, A Castagna, G Gaiera

Research output: Contribution to journalArticle

Abstract

Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas. © 2017, Pontificia Universidad Catolica de Chile, Facultad de Agronomia e Ingenieria Forestal. All rights Recived.
Original languageEnglish
Pages (from-to)452-455
Number of pages4
JournalMemorias do Instituto Oswaldo Cruz
Volume112
Issue number6
DOIs
Publication statusPublished - 2017

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