TY - JOUR
T1 - The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma Mansoni infection in migrants in Italy, a non-endemic country: A cross sectional study
AU - Infurnari, L
AU - Galli, L
AU - Bigoloni, A
AU - Carbone, A
AU - Chiappetta, S
AU - Sala, A
AU - Ceserani, N
AU - Lazzarin, A
AU - Castagna, A
AU - Gaiera, G
PY - 2017
Y1 - 2017
N2 - Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas. © 2017, Pontificia Universidad Catolica de Chile, Facultad de Agronomia e Ingenieria Forestal. All rights Recived.
AB - Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas. © 2017, Pontificia Universidad Catolica de Chile, Facultad de Agronomia e Ingenieria Forestal. All rights Recived.
U2 - 10.1590/0074-02760160355
DO - 10.1590/0074-02760160355
M3 - Article
VL - 112
SP - 452
EP - 455
JO - Memorias do Instituto Oswaldo Cruz
JF - Memorias do Instituto Oswaldo Cruz
SN - 0074-0276
IS - 6
ER -