The use of electrical source imaging in targeting lesional mesial temporal epilepsy for radiosurgical treatment

Alessandra Del Felice, Roberto Foroni, Paolo Manganotti, Silvia F. Storti, Giuseppe K. Ricciardi, Dafna Ben Bashat, Michele Longhi, Mario Meglio, Antonio Nicolato

Research output: Contribution to journalArticlepeer-review


Gamma knife radiosurgery (GK-RS) is a technique applied in selected cases of mesial-temporal epilepsy, although still limited to centres with adequate instrumentation and expertise. Here, we report a case of radio surgery targeted with the aid of electrical source imaging that localizes the cortical area generating the scalp epileptic discharges. The patient, a 39-year-old male, presented with a right mesio-temporal lesion; electrical source imaging localization partially overlapped with the lesional area but showed an important activation of the omolateral frontal area, concordant with the epileptic network. The patient underwent GK-RS, with good neurosurgical and clinical results. A radiosurgical ellipsoidal treatment volume area of 2×2×2 cm3, located over the right temporo-mesial region within a centre showing abnormal signal intensity, was considered. Seven months after treatment, the patient developed brain oedema that gradually resolved after one year. After three years of follow-up, the patient was seizure-free (Engel class I). Our very preliminary experience suggests that electrical source imaging appears to be a useful supporting tool for the definition of the radiosurgical treatment volume in selected patients with temporo-mesial lesional epilepsy.

Original languageEnglish
Pages (from-to)528-532
Number of pages5
JournalEpileptic Disorders
Issue number4
Publication statusPublished - Dec 1 2014


  • Epilepsy surgery
  • Inverse solution problem
  • Radiosurgery high-density EEG

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)


Dive into the research topics of 'The use of electrical source imaging in targeting lesional mesial temporal epilepsy for radiosurgical treatment'. Together they form a unique fingerprint.

Cite this