The use of hematopoietic stem cells in autoimmune diseases

Moufida Ben Nasr, Roberto Bassi, Vera Usuelli, Alessandro Valderrama-Vasquez, Sara Tezza, Francesca D'Addio, Paolo Fiorina

Research output: Contribution to journalReview article

Abstract

Hematopoietic stem cells (HSCs) have been shown recently to hold much promise in curing autoimmune diseases. Newly diagnosed Type 1 diabetes individuals have been successfully reverted to normoglycemia by administration of autologous HSCs in association with a nonmyeloablative regimen (antithymocyte globulin + cyclophasmide). Furthermore, recent trials reported positive results by using HSCs in treatment of systemic sclerosis, multiple sclerosis and rheumatoid arthritis as well. Early data suggested that HSCs possess immunological properties that may be harnessed to alleviate the symptoms of individuals with autoimmune disorders and possibly induce remission of autoimmune diseases. Mechanistically, HSCs may facilitate the generation of regulatory T cells, may inhibit the function of autoreactive T-cell function and may reshape the immune system.

Original languageEnglish
Pages (from-to)395-405
Number of pages11
JournalRegenerative Medicine
Volume11
Issue number4
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • autoimmune diseases
  • hematopoietic stem cells
  • Type 1 diabetes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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    Ben Nasr, M., Bassi, R., Usuelli, V., Valderrama-Vasquez, A., Tezza, S., D'Addio, F., & Fiorina, P. (2016). The use of hematopoietic stem cells in autoimmune diseases. Regenerative Medicine, 11(4), 395-405. https://doi.org/10.2217/rme-2015-0057