The use of household cleaning sprays and adult asthma: An international longitudinal study

Jan Paul Zock, Estel Plana, Deborah Jarvis, Josep M. Antó, Hans Kromhout, Susan M. Kennedy, Nino Künzli, Simona Villani, Mario Olivieri, Kjell Torén, Katja Radon, Jordi Sunyer, Anna Dahlman-Hoglund, Dan Norbäck, Manolis Kogevinas, J. Knox, J. Potts, S. Arinze, M. Burrows, S. HughesK. Cheema, Josep M. Antó, Peter Burney, Isa Cerveri, Susan Chinn, Christina Luczynska, Roberto de Marco, Thorarinn Gislason, Joachim Heinrich, Matthias Wjst, Christer Janson, Nino Künzli, Bénédicte Leynaert, Françoise Neukirch, J. Schouten, Cecilie Svanes, Paul Vermeire, J. Weyler, M. Van Sprundel, V. Nelen, R. Jogi, A. Soon, R. Liard, M. Zureik, I. Pin, J. Ferran-Quentin, C. Frye, I. Meyer, M. Bugiani, P. Piccioni, A. Carosso, W. Arossa, E. Caria, G. Castiglioni, E. Migliore, C. Romano, D. Fabbro, G. Ciccone, C. Magnani, P. Dalmasso, R. Bono, G. Gigli, A. Giraudo, M. C. Brussino, C. Bucca, G. Rolla, G. Verlato, E. Zanolin, S. Accordini, A. Poli, V. Lo Cascio, M. Ferrari, A. Marinoni, M. Ponzio, F. Frigerio, M. Comelli, M. Grassi, A. Corsico, A. Gulsvik, E. Omenaas, B. Laerum, X. Basagana, A. Jaen, F. Burgos, J. Maldonado, A. Pereira, J. L. Sanchez, J. Martinez-Moratalla Rovira, E. Almar, N. Muniozguren, I. Urritia, F. Payo, G. Boman, D. Norback, M. Gunnbjornsdottir, K. Toren, L. Lillienberg, A. Dahlman-Höglund, R. Sundberg, E. Norrman, M. Soderberg, K. Franklin, B. Lundback, B. Forsberg, L. Nystrom, B. Dibbert, M. Hazenkamp, M. Brutsche, U. Ackermann-Liebrich, B. Harrison, R. Hall, D. Seaton

Research output: Contribution to journalArticle

Abstract

Rationale: Cleaning work and professional use of certain cleaning products have been associated with asthma, but respiratory effects of nonprofessional home cleaning have rarely been studied. Objectives: To investigate the risk of new-onset asthma in relation to the use of common household cleaners. Methods: Within the follow-up of the European Community Respiratory Health Survey in 10 countries, we identified 3,503 persons doing the cleaning in their homes and who were free of asthma at baseline. Frequency of use of 15 types of cleaning products was obtained in a face-to-face interview at follow-up. We studied the incidence of asthma defined as physician diagnosis and as symptoms or medication usage at follow-up. Associations between asthma and the use of cleaning products were evaluated using multivariable Cox proportional hazards or log-binomial regression analysis. Measurements and Main Results: The use of cleaning sprays at least weekly (42% of participants) was associated with the incidence of asthma symptoms or medication (relative risk [RR], 1.49; 95% confidence interval [CI], 1.12-1.99) and wheeze (RR, 1.39; 95% CI, 1.06-1.80). The incidence of physician-diagnosed asthma was higher among those using sprays at least 4 days per week (RR, 2.11; 95% CI, 1.15-3.89). These associations were consistent for subgroups and not modified by atopy. Dose-response relationships (P <0.05) were apparent for the frequency of use and the number of different sprays. Risks were predominantly found for the commonly used glass-cleaning, furniture, and air-refreshing sprays. Cleaning products not applied in spray form were not associated with asthma. Conclusions: Frequent use of common household cleaning sprays may be an important risk factor for adult asthma.

Original languageEnglish
Pages (from-to)735-741
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume176
Issue number8
DOIs
Publication statusPublished - Oct 15 2007

Keywords

  • Airway irritants
  • ECRHS
  • Epidemiology
  • Incidence

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Zock, J. P., Plana, E., Jarvis, D., Antó, J. M., Kromhout, H., Kennedy, S. M., Künzli, N., Villani, S., Olivieri, M., Torén, K., Radon, K., Sunyer, J., Dahlman-Hoglund, A., Norbäck, D., Kogevinas, M., Knox, J., Potts, J., Arinze, S., Burrows, M., ... Seaton, D. (2007). The use of household cleaning sprays and adult asthma: An international longitudinal study. American Journal of Respiratory and Critical Care Medicine, 176(8), 735-741. https://doi.org/10.1164/rccm.200612-1793OC