Abstract
Introduction Immunosuppressive agents (ISA) have been used in multiple sclerosis (MS) for decades, frequently as off label licensed therapies. Given the new MS treatment landscape, what place do ISA have in combating MS? Methods We conducted a retrospective multicentre study to investigate the frequency of ISA prescription in 17 Italian MS centres, and to describe the clinical factors related to ISA use. Results Out of 6,447 MS patients, 2,034 (31.6%) were treated with ISA, with Azathioprine being the most frequently used ISA overall. MS patients treated with ISA alone were more frequently affected by the progressive course (both primary and secondary) of the disease (RRR 5.82, 95% CI 4.14-8.16, p
| Original language | English |
|---|---|
| Article number | e0157721 |
| Journal | PLoS One |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2016 |
Fingerprint
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
The use of immunosuppressant therapy for multiple sclerosis in Italy : A multicenter retroprospective study. / D'Amico, Emanuele; Leone, C.; Graziano, Giusi; Amato, Maria Pia; Bergamaschi, Roberto; Cavalla, P.; Coniglio, G.; Di Battista, Giancarlo; Ferrò, Maria T.; Granella, Franco; Granieri, Enrico; Lugaresi, Alessandra; Lus, G.; Millefiorini, E.; Pozzilli, C.; Tedeschi, G.; Zappia, Mario; Comi, Giancarlo; Trojano, Maria; Lepore, V.; Patti, Francesco.
In: PLoS One, Vol. 11, No. 6, e0157721, 01.06.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The use of immunosuppressant therapy for multiple sclerosis in Italy
T2 - A multicenter retroprospective study
AU - D'Amico, Emanuele
AU - Leone, C.
AU - Graziano, Giusi
AU - Amato, Maria Pia
AU - Bergamaschi, Roberto
AU - Cavalla, P.
AU - Coniglio, G.
AU - Di Battista, Giancarlo
AU - Ferrò, Maria T.
AU - Granella, Franco
AU - Granieri, Enrico
AU - Lugaresi, Alessandra
AU - Lus, G.
AU - Millefiorini, E.
AU - Pozzilli, C.
AU - Tedeschi, G.
AU - Zappia, Mario
AU - Comi, Giancarlo
AU - Trojano, Maria
AU - Lepore, V.
AU - Patti, Francesco
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Introduction Immunosuppressive agents (ISA) have been used in multiple sclerosis (MS) for decades, frequently as off label licensed therapies. Given the new MS treatment landscape, what place do ISA have in combating MS? Methods We conducted a retrospective multicentre study to investigate the frequency of ISA prescription in 17 Italian MS centres, and to describe the clinical factors related to ISA use. Results Out of 6,447 MS patients, 2,034 (31.6%) were treated with ISA, with Azathioprine being the most frequently used ISA overall. MS patients treated with ISA alone were more frequently affected by the progressive course (both primary and secondary) of the disease (RRR 5.82, 95% CI 4.14-8.16, p
AB - Introduction Immunosuppressive agents (ISA) have been used in multiple sclerosis (MS) for decades, frequently as off label licensed therapies. Given the new MS treatment landscape, what place do ISA have in combating MS? Methods We conducted a retrospective multicentre study to investigate the frequency of ISA prescription in 17 Italian MS centres, and to describe the clinical factors related to ISA use. Results Out of 6,447 MS patients, 2,034 (31.6%) were treated with ISA, with Azathioprine being the most frequently used ISA overall. MS patients treated with ISA alone were more frequently affected by the progressive course (both primary and secondary) of the disease (RRR 5.82, 95% CI 4.14-8.16, p
UR - http://www.scopus.com/inward/record.url?scp=84978139141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84978139141&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0157721
DO - 10.1371/journal.pone.0157721
M3 - Article
VL - 11
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 6
M1 - e0157721
ER -