The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone

Luigi Gennari; Daniela Merlotti; Giuseppe Mossetti; Domenico Rendina; Vincenzo De Paola; Giuseppe Martini; Ranuccio Nuti

doi:10.2174/138955709788922683

The use of intravenous aminobisphosphonates for the treatment of Paget's disease of bone

Luigi Gennari, Daniela Merlotti, Giuseppe Mossetti, Domenico Rendina, Vincenzo De Paola, Giuseppe Martini, Ranuccio Nuti

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.

Original language	English
Pages (from-to)	1052-1063
Number of pages	12
Journal	Mini-Reviews in Medicinal Chemistry
Volume	9
Issue number	9
DOIs	https://doi.org/10.2174/138955709788922683
Publication status	Published - 2009

Keywords

Bisphosphonates
Bone turnover
Neridronate
Paget's disease of bone
Pamidronate
Zoledronic acid

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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AU - Gennari, Luigi

AU - Merlotti, Daniela

AU - Mossetti, Giuseppe

AU - Rendina, Domenico

AU - De Paola, Vincenzo

AU - Martini, Giuseppe

AU - Nuti, Ranuccio

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AB - Paget's disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.

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KW - Paget's disease of bone

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KW - Zoledronic acid

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