The use of mannitol in partial and live donor nephrectomy

An international survey

M. Cosentino, A. Breda, F. Sanguedolce, J. Landman, J. U. Stolzenburg, P. Verze, J. Rassweiler, H. Van Poppel, H. C. Klingler, G. Janetschek, A. Celia, F. J. Kim, G. Thalmann, U. Nagele, A. Mogorovich, C. Bolenz, T. Knoll, F. Porpiglia, M. Alvarez-Maestro, F. Francesca & 18 others F. Deho, S. Eggener, C. Abbou, M. V. Meng, M. Aron, P. Laguna, D. Mladenov, A. D'Addessi, P. Bove, R. Schiavina, O. De Cobelli, A. S. Merseburger, O. Dalpiaz, F. C H D'Ancona, T. J. Polascik, R. Muschter, T. J. Leppert, H. Villavicencio

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Purpose: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. Materials and methods: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures. Results: Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection. Conclusions: A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.

Original languageEnglish
Pages (from-to)977-982
Number of pages6
JournalWorld Journal of Urology
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Mannitol
Nephrectomy
Tissue Donors
Surveys and Questionnaires
Antioxidants
Prospective Studies
Warm Ischemia
Furosemide
Diuretics
Anti-Inflammatory Agents
Physicians

Keywords

  • Diuretics
  • Live donor nephrectomy
  • Mannitol
  • Partial nephrectomy
  • Renoprotective agent

ASJC Scopus subject areas

  • Urology

Cite this

Cosentino, M., Breda, A., Sanguedolce, F., Landman, J., Stolzenburg, J. U., Verze, P., ... Villavicencio, H. (2013). The use of mannitol in partial and live donor nephrectomy: An international survey. World Journal of Urology, 31(4), 977-982. https://doi.org/10.1007/s00345-012-1003-1

The use of mannitol in partial and live donor nephrectomy : An international survey. / Cosentino, M.; Breda, A.; Sanguedolce, F.; Landman, J.; Stolzenburg, J. U.; Verze, P.; Rassweiler, J.; Van Poppel, H.; Klingler, H. C.; Janetschek, G.; Celia, A.; Kim, F. J.; Thalmann, G.; Nagele, U.; Mogorovich, A.; Bolenz, C.; Knoll, T.; Porpiglia, F.; Alvarez-Maestro, M.; Francesca, F.; Deho, F.; Eggener, S.; Abbou, C.; Meng, M. V.; Aron, M.; Laguna, P.; Mladenov, D.; D'Addessi, A.; Bove, P.; Schiavina, R.; De Cobelli, O.; Merseburger, A. S.; Dalpiaz, O.; D'Ancona, F. C H; Polascik, T. J.; Muschter, R.; Leppert, T. J.; Villavicencio, H.

In: World Journal of Urology, Vol. 31, No. 4, 08.2013, p. 977-982.

Research output: Contribution to journalArticle

Cosentino, M, Breda, A, Sanguedolce, F, Landman, J, Stolzenburg, JU, Verze, P, Rassweiler, J, Van Poppel, H, Klingler, HC, Janetschek, G, Celia, A, Kim, FJ, Thalmann, G, Nagele, U, Mogorovich, A, Bolenz, C, Knoll, T, Porpiglia, F, Alvarez-Maestro, M, Francesca, F, Deho, F, Eggener, S, Abbou, C, Meng, MV, Aron, M, Laguna, P, Mladenov, D, D'Addessi, A, Bove, P, Schiavina, R, De Cobelli, O, Merseburger, AS, Dalpiaz, O, D'Ancona, FCH, Polascik, TJ, Muschter, R, Leppert, TJ & Villavicencio, H 2013, 'The use of mannitol in partial and live donor nephrectomy: An international survey', World Journal of Urology, vol. 31, no. 4, pp. 977-982. https://doi.org/10.1007/s00345-012-1003-1
Cosentino M, Breda A, Sanguedolce F, Landman J, Stolzenburg JU, Verze P et al. The use of mannitol in partial and live donor nephrectomy: An international survey. World Journal of Urology. 2013 Aug;31(4):977-982. https://doi.org/10.1007/s00345-012-1003-1
Cosentino, M. ; Breda, A. ; Sanguedolce, F. ; Landman, J. ; Stolzenburg, J. U. ; Verze, P. ; Rassweiler, J. ; Van Poppel, H. ; Klingler, H. C. ; Janetschek, G. ; Celia, A. ; Kim, F. J. ; Thalmann, G. ; Nagele, U. ; Mogorovich, A. ; Bolenz, C. ; Knoll, T. ; Porpiglia, F. ; Alvarez-Maestro, M. ; Francesca, F. ; Deho, F. ; Eggener, S. ; Abbou, C. ; Meng, M. V. ; Aron, M. ; Laguna, P. ; Mladenov, D. ; D'Addessi, A. ; Bove, P. ; Schiavina, R. ; De Cobelli, O. ; Merseburger, A. S. ; Dalpiaz, O. ; D'Ancona, F. C H ; Polascik, T. J. ; Muschter, R. ; Leppert, T. J. ; Villavicencio, H. / The use of mannitol in partial and live donor nephrectomy : An international survey. In: World Journal of Urology. 2013 ; Vol. 31, No. 4. pp. 977-982.
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abstract = "Purpose: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. Materials and methods: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures. Results: Mannitol was used in 78 and 64 {\%} of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 {\%}), as diuretic (5 {\%}) and as a combination of the two (74 {\%}). For PN, the most common dosages were 12.5 g (30 {\%}) and 25 g (49 {\%}). For LDN, the most common doses were 12.5 g (36.3 {\%}) and 25 g (63.7 {\%}). Overall, 83 {\%} of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection. Conclusions: A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.",
keywords = "Diuretics, Live donor nephrectomy, Mannitol, Partial nephrectomy, Renoprotective agent",
author = "M. Cosentino and A. Breda and F. Sanguedolce and J. Landman and Stolzenburg, {J. U.} and P. Verze and J. Rassweiler and {Van Poppel}, H. and Klingler, {H. C.} and G. Janetschek and A. Celia and Kim, {F. J.} and G. Thalmann and U. Nagele and A. Mogorovich and C. Bolenz and T. Knoll and F. Porpiglia and M. Alvarez-Maestro and F. Francesca and F. Deho and S. Eggener and C. Abbou and Meng, {M. V.} and M. Aron and P. Laguna and D. Mladenov and A. D'Addessi and P. Bove and R. Schiavina and {De Cobelli}, O. and Merseburger, {A. S.} and O. Dalpiaz and D'Ancona, {F. C H} and Polascik, {T. J.} and R. Muschter and Leppert, {T. J.} and H. Villavicencio",
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T1 - The use of mannitol in partial and live donor nephrectomy

T2 - An international survey

AU - Cosentino, M.

AU - Breda, A.

AU - Sanguedolce, F.

AU - Landman, J.

AU - Stolzenburg, J. U.

AU - Verze, P.

AU - Rassweiler, J.

AU - Van Poppel, H.

AU - Klingler, H. C.

AU - Janetschek, G.

AU - Celia, A.

AU - Kim, F. J.

AU - Thalmann, G.

AU - Nagele, U.

AU - Mogorovich, A.

AU - Bolenz, C.

AU - Knoll, T.

AU - Porpiglia, F.

AU - Alvarez-Maestro, M.

AU - Francesca, F.

AU - Deho, F.

AU - Eggener, S.

AU - Abbou, C.

AU - Meng, M. V.

AU - Aron, M.

AU - Laguna, P.

AU - Mladenov, D.

AU - D'Addessi, A.

AU - Bove, P.

AU - Schiavina, R.

AU - De Cobelli, O.

AU - Merseburger, A. S.

AU - Dalpiaz, O.

AU - D'Ancona, F. C H

AU - Polascik, T. J.

AU - Muschter, R.

AU - Leppert, T. J.

AU - Villavicencio, H.

PY - 2013/8

Y1 - 2013/8

N2 - Purpose: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. Materials and methods: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures. Results: Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection. Conclusions: A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.

AB - Purpose: Animal studies have shown the potential benefits of mannitol as renoprotective during warm ischemia; it may have antioxidant and anti-inflammatory properties and is sometimes used during partial nephrectomy (PN) and live donor nephrectomy (LDN). Despite this, a prospective study on mannitol has never been performed. The aim of this study is to document patterns of mannitol use during PN and LDN. Materials and methods: A survey on the use of mannitol during PN and LDN was sent to 92 high surgical volume urological centers. Questions included use of mannitol, indications for use, physician responsible for administration, dosage, timing and other renoprotective measures. Results: Mannitol was used in 78 and 64 % of centers performing PN and LDN, respectively. The indication for use was as antioxidant (21 %), as diuretic (5 %) and as a combination of the two (74 %). For PN, the most common dosages were 12.5 g (30 %) and 25 g (49 %). For LDN, the most common doses were 12.5 g (36.3 %) and 25 g (63.7 %). Overall, 83 % of centers utilized mannitol, and two (percent or centers??) utilized furosemide for renoprotection. Conclusions: A large majority of high-volume centers performing PN and LDN use mannitol for renoprotection. Since there are no data proving its value nor standardized indication and usage, this survey may provide information for a randomized prospective study.

KW - Diuretics

KW - Live donor nephrectomy

KW - Mannitol

KW - Partial nephrectomy

KW - Renoprotective agent

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