Abstract
Even if minoxidil has been known for over 30 years as "hair growth stimulator" the precise mechanism of its action is not completely elucitated. Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase. Moreover, minoxidil increases hair follicle size. A large part of hair treatment scientific literature confirms the efficacy of topically applied minoxidil in humans. In particular, patients treated with minoxidil showed a significant increase in "non vellus" hair count starting from baseline. Preparation of minoxidil requires molecule stability and solubility. Today are available on the market minoxidil-based formulations having low-concentration of propylene glycol to obtain preparations with a better cosmetical acceptance and dermatological safety. The body of evidences indicates that minoxidil still represent a milestone in the treatment of androgenetic alopecia and that its story is going on.
| Original language | English |
|---|---|
| Pages (from-to) | 102-106 |
| Number of pages | 5 |
| Journal | Giornale Italiano di Dermatologia e Venereologia |
| Volume | 153 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Feb 1 2018 |
| Externally published | Yes |
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Keywords
- Alopecia
- Minoxidil
- Propylene glycol
- Treatment outcome
ASJC Scopus subject areas
- Dermatology
Cite this
The use of minoxidil in the treatment of male and female androgenetic alopecia : A story of more than 30 years. / Barbareschi, Mauro.
In: Giornale Italiano di Dermatologia e Venereologia, Vol. 153, No. 1, 01.02.2018, p. 102-106.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The use of minoxidil in the treatment of male and female androgenetic alopecia
T2 - A story of more than 30 years
AU - Barbareschi, Mauro
PY - 2018/2/1
Y1 - 2018/2/1
N2 - Even if minoxidil has been known for over 30 years as "hair growth stimulator" the precise mechanism of its action is not completely elucitated. Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase. Moreover, minoxidil increases hair follicle size. A large part of hair treatment scientific literature confirms the efficacy of topically applied minoxidil in humans. In particular, patients treated with minoxidil showed a significant increase in "non vellus" hair count starting from baseline. Preparation of minoxidil requires molecule stability and solubility. Today are available on the market minoxidil-based formulations having low-concentration of propylene glycol to obtain preparations with a better cosmetical acceptance and dermatological safety. The body of evidences indicates that minoxidil still represent a milestone in the treatment of androgenetic alopecia and that its story is going on.
AB - Even if minoxidil has been known for over 30 years as "hair growth stimulator" the precise mechanism of its action is not completely elucitated. Minoxidil shortens telogen, accelerates telogen-exogen phase and causes the premature entry of resting hair follicles into anagen phase. Moreover, minoxidil increases hair follicle size. A large part of hair treatment scientific literature confirms the efficacy of topically applied minoxidil in humans. In particular, patients treated with minoxidil showed a significant increase in "non vellus" hair count starting from baseline. Preparation of minoxidil requires molecule stability and solubility. Today are available on the market minoxidil-based formulations having low-concentration of propylene glycol to obtain preparations with a better cosmetical acceptance and dermatological safety. The body of evidences indicates that minoxidil still represent a milestone in the treatment of androgenetic alopecia and that its story is going on.
KW - Alopecia
KW - Minoxidil
KW - Propylene glycol
KW - Treatment outcome
UR - http://www.scopus.com/inward/record.url?scp=85040824812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040824812&partnerID=8YFLogxK
U2 - 10.23736/S0392-0488.17.05781-9
DO - 10.23736/S0392-0488.17.05781-9
M3 - Review article
AN - SCOPUS:85040824812
VL - 153
SP - 102
EP - 106
JO - Minerva dermatologica
JF - Minerva dermatologica
SN - 0392-0488
IS - 1
ER -