The use of platelet-rich plasma gel in patients with mixed tumour undergoing superficial parotidectomy: A randomized study

Marco Scala, Paola Mereu, Francesco Spagnolo, Michela Massa, Annalisa Barla, Sofia Mosci, Gilberto Forno, Andra Ingenito, Paolo Strada

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: Salivary gland tumors are mostly benign tumors. Whether a more conservative surgical approach at greater risk of recurrence, or a more radical intervention with an increased risk of facial paralysis is warranted is still under discussion. Our study addresses the opportunity for improving surgical outcome by employing platelet-rich plasma (PRP) gel at the surgical site. Patients and Methods: Twenty consecutive patients undergoing superficial parotidectomy were randomized and assigned to two groups, one with and one without PRP gel. Many parameters were evaluated after surgery and during follow-up, such as the duration of hospitalization, facial nerve deficit, onset of Frey's syndrome, relapse, cosmetic results, presence of keloid or scar depressions, behavior of several facial muscles. Results: Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients undergoing parotidectomy, whereas no negative effects were detected. Conclusion: This work suggests that administration of PRP in patients undergoing parotidectomy is beneficial.

Original languageEnglish
Pages (from-to)121-124
Number of pages4
JournalIn Vivo
Volume28
Issue number1
Publication statusPublished - 2014

Keywords

  • Parotidectomy
  • Platelet gel
  • Platelet-rich plasma
  • Regenerative medicine
  • Salivary gland tumors

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology
  • Medicine(all)

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