TY - JOUR
T1 - The use of platelet-rich plasma gel in patients with mixed tumour undergoing superficial parotidectomy
T2 - A randomized study
AU - Scala, Marco
AU - Mereu, Paola
AU - Spagnolo, Francesco
AU - Massa, Michela
AU - Barla, Annalisa
AU - Mosci, Sofia
AU - Forno, Gilberto
AU - Ingenito, Andra
AU - Strada, Paolo
PY - 2014
Y1 - 2014
N2 - Background/Aim: Salivary gland tumors are mostly benign tumors. Whether a more conservative surgical approach at greater risk of recurrence, or a more radical intervention with an increased risk of facial paralysis is warranted is still under discussion. Our study addresses the opportunity for improving surgical outcome by employing platelet-rich plasma (PRP) gel at the surgical site. Patients and Methods: Twenty consecutive patients undergoing superficial parotidectomy were randomized and assigned to two groups, one with and one without PRP gel. Many parameters were evaluated after surgery and during follow-up, such as the duration of hospitalization, facial nerve deficit, onset of Frey's syndrome, relapse, cosmetic results, presence of keloid or scar depressions, behavior of several facial muscles. Results: Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients undergoing parotidectomy, whereas no negative effects were detected. Conclusion: This work suggests that administration of PRP in patients undergoing parotidectomy is beneficial.
AB - Background/Aim: Salivary gland tumors are mostly benign tumors. Whether a more conservative surgical approach at greater risk of recurrence, or a more radical intervention with an increased risk of facial paralysis is warranted is still under discussion. Our study addresses the opportunity for improving surgical outcome by employing platelet-rich plasma (PRP) gel at the surgical site. Patients and Methods: Twenty consecutive patients undergoing superficial parotidectomy were randomized and assigned to two groups, one with and one without PRP gel. Many parameters were evaluated after surgery and during follow-up, such as the duration of hospitalization, facial nerve deficit, onset of Frey's syndrome, relapse, cosmetic results, presence of keloid or scar depressions, behavior of several facial muscles. Results: Our explorative analysis suggests a positive effect of PRP on surgical outcome in patients undergoing parotidectomy, whereas no negative effects were detected. Conclusion: This work suggests that administration of PRP in patients undergoing parotidectomy is beneficial.
KW - Parotidectomy
KW - Platelet gel
KW - Platelet-rich plasma
KW - Regenerative medicine
KW - Salivary gland tumors
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M3 - Article
C2 - 24425846
AN - SCOPUS:84906928338
VL - 28
SP - 121
EP - 124
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 1
ER -