The use of tamsulosin in the medical treatment of ureteral calculi: Where do we stand?

Riccardo Autorino, Marco De Sio, Rocco Damiano, Giuseppe Di Lorenzo, Sisto Perdonà, Aniello Russo, Giuseppe Quarto, Luca Cosentino, Massimo D'Armiento

Research output: Contribution to journalArticle

Abstract

It has recently been demonstrated that specific adrenoceptors subtypes (α1A1D) are prevalent in the distal part of the ureter, a finding supporting the interesting results obtained by different groups with the use of tamsulosin in the treatment of distal ureteral calculi. We performed a prospective randomized study to evaluate the effects of the addition of tamsulosin on our standard pharmacological therapy for the treatment of selected ureteral stones. A total of 64 patients referred to our department for the management of symptomatic ureteral calculi were considered. Patients were randomly divided into two treatment groups: group A (n = 32) who received diclofenac (100 mg/daily) plus aescin (80 mg/ daily) and group B (n = 32) who received the same therapy plus tamsulosin (0.4 mg/daily) for a maximum of 2 weeks. No significant differences were found between the groups for age, gender distribution and mean stone size measured in the single largest dimension at presentation. The stone expulsion rate was 60% (19/32 patients) for group A and 88% for (28/32) for group B with a mean expulsion time of 7.4 ± 2.2 (range 3.5-12) and 4.8 ± 2.7 days (range 1.8-10.5), respectively. Group B showed a significant advantage in terms of both expulsion rate (P = 0.01) and expulsion time (P = 0.005). Different analgesics from those used in the standard treatment regimen were required in ten patients in group A (31%) but only three patients in group B (9%). This difference was significant (P = 0.003). Hospitalization for recurrent colic was needed in 21 % of patients in group A (7/32) and in 9% in group B (3/32) (P = 0.01). Only two patients in each group (6%) experienced minor side effects associated with the expulsive therapy. Our data confirm the efficacy of tamsulosin in the treatment of distal ureteral stones up to 1 cm. This selective α-blocker should therefore be included in the pharmacological regimen of patients when a conservative approach is considered in the treatment of ureteral lithiasis.

Original languageEnglish
Pages (from-to)460-464
Number of pages5
JournalUrological Research
Volume33
Issue number6
DOIs
Publication statusPublished - Dec 2005

Fingerprint

tamsulosin
Ureteral Calculi
Therapeutics
Escin
Pharmacology
Lithiasis
Colic
Diclofenac
Age Distribution
Ureter

Keywords

  • Medical treatment
  • Tamsulosin
  • Ureteral stones

ASJC Scopus subject areas

  • Urology

Cite this

Autorino, R., De Sio, M., Damiano, R., Di Lorenzo, G., Perdonà, S., Russo, A., ... D'Armiento, M. (2005). The use of tamsulosin in the medical treatment of ureteral calculi: Where do we stand? Urological Research, 33(6), 460-464. https://doi.org/10.1007/s00240-005-0508-0

The use of tamsulosin in the medical treatment of ureteral calculi : Where do we stand? / Autorino, Riccardo; De Sio, Marco; Damiano, Rocco; Di Lorenzo, Giuseppe; Perdonà, Sisto; Russo, Aniello; Quarto, Giuseppe; Cosentino, Luca; D'Armiento, Massimo.

In: Urological Research, Vol. 33, No. 6, 12.2005, p. 460-464.

Research output: Contribution to journalArticle

Autorino, R, De Sio, M, Damiano, R, Di Lorenzo, G, Perdonà, S, Russo, A, Quarto, G, Cosentino, L & D'Armiento, M 2005, 'The use of tamsulosin in the medical treatment of ureteral calculi: Where do we stand?', Urological Research, vol. 33, no. 6, pp. 460-464. https://doi.org/10.1007/s00240-005-0508-0
Autorino, Riccardo ; De Sio, Marco ; Damiano, Rocco ; Di Lorenzo, Giuseppe ; Perdonà, Sisto ; Russo, Aniello ; Quarto, Giuseppe ; Cosentino, Luca ; D'Armiento, Massimo. / The use of tamsulosin in the medical treatment of ureteral calculi : Where do we stand?. In: Urological Research. 2005 ; Vol. 33, No. 6. pp. 460-464.
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