The usefulness of 99mTc-tetrofosmin SPECT in monitoring the response to chemotherapy in lung cancer patients.

Angela Spanu, Francesco Ginesu, Pietro Pirina, Orazio Schillaci, Antonio Farris, Francesca Chessa, Giordano Madeddu, Antonio Falchi, Giuseppe Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the usefulness of 99mTc-tetrofosmin (TF) scintigraphy in monitoring chemotherapy response in 31 inoperable lung cancer (LC) patients, 24 NSCLC and 7 SCLC. In all cases after 740 MBq 99mTc-TF i.v. injection both planar and SPECT images were acquired, before and after 3 cycles of chemotherapy; SPECT was analysed both qualitatively and semiquantitatively by calculating tumor/background ratio (T/B). Scintigraphic data were always related to CT findings, according to which patients were classified into 2 groups after therapy: responders (with >or=50% reduction in tumor size) and non-responders (with an increase or no change/no significant reduction in tumor size). Four patients were rechecked for the third time, during long-term follow-up. SPECT images, positive before therapy in all cases, were concordant with CT in assessing treatment response in 13/13 responders and in 18/18 non-responder patients, showing tumor reduction in the former and an increase or no change/no significant reduction in the latter. Planar imaging failed to give additional information but also led to disease down-staging in some cases. T/B ratio significantly decreased after therapy (1.67+/-0.39 vs. 3.02+/-0.87, p

Original languageEnglish
Pages (from-to)1701-1707
Number of pages7
JournalOncology Reports
Volume10
Issue number6
Publication statusPublished - Nov 2003

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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