The vacuolating toxin of Helicobacter pylori mimicks the CFTR-mediated chloride conductance

Silvia Campello, Francesco Tombola, Giulio Cabrini, Mario Zoratti

Research output: Contribution to journalArticle

Abstract

Cystic fibrosis (CF) is caused by defects of the CF transmembrane conductance regulator (CFTR), which acts both as an anion-selective channel and as a regulator of other proteins. The relative contribution of these two functions in CF disease is debated. The toxin VacA forms channels with properties similar to those of the CFTR, and we report here that it can insert into the membrane of various cells originating from respiratory epithelia, generating a chloride conductance comparable to that produced by activation of the CFTR. VacA may therefore become a valuable tool in the study of CF pathogenesis.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalFEBS Letters
Volume532
Issue number1-2
DOIs
Publication statusPublished - Dec 4 2002

Keywords

  • Chloride channel
  • Cystic fibrosis
  • Cystic fibrosis transmembrane conductance regulator
  • Helicobacter pylori
  • Respiratory epithelium
  • VacA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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